[HTML][HTML] Insights on the emerging biotechnology of histidine-rich peptides
In the late 70's, the discovery of the restriction enzymes made possible the biological
production of functional proteins by recombinant DNA technologies, a fact that largely …
production of functional proteins by recombinant DNA technologies, a fact that largely …
Apical membrane antigen 1: a malaria vaccine candidate in review
EJ Remarque, BW Faber, CHM Kocken… - Trends in …, 2008 - cell.com
Apical membrane antigen 1 (AMA1) is a micronemal protein of apicomplexan parasites that
appears to be essential during the invasion of host cells. Immune responses to Plasmodium …
appears to be essential during the invasion of host cells. Immune responses to Plasmodium …
Structure-based design of a strain transcending AMA1-RON2L malaria vaccine
Abstract Apical membrane antigen 1 (AMA1) is a key malaria vaccine candidate and target
of neutralizing antibodies. AMA1 binds to a loop in rhoptry neck protein 2 (RON2L) to form …
of neutralizing antibodies. AMA1 binds to a loop in rhoptry neck protein 2 (RON2L) to form …
A field trial to assess a blood-stage malaria vaccine
MA Thera, OK Doumbo, D Coulibaly… - … England Journal of …, 2011 - Mass Medical Soc
Background Blood-stage malaria vaccines are intended to prevent clinical disease. The
malaria vaccine FMP2. 1/AS02A, a recombinant protein based on apical membrane antigen …
malaria vaccine FMP2. 1/AS02A, a recombinant protein based on apical membrane antigen …
Breadth and Magnitude of Antibody Responses to Multiple Plasmodium falciparum Merozoite Antigens Are Associated with Protection from Clinical Malaria
Individuals living in areas where malaria is endemic are repeatedly exposed to many
different malaria parasite antigens. Studies on naturally acquired antibody-mediated …
different malaria parasite antigens. Studies on naturally acquired antibody-mediated …
Stable and unstable malaria hotspots in longitudinal cohort studies in Kenya
Background Infectious diseases often demonstrate heterogeneity of transmission among
host populations. This heterogeneity reduces the efficacy of control strategies, but also …
host populations. This heterogeneity reduces the efficacy of control strategies, but also …
New antigens for a multicomponent blood-stage malaria vaccine
An effective blood-stage vaccine against Plasmodium falciparum remains a research
priority, but the number of antigens that have been translated into multicomponent vaccines …
priority, but the number of antigens that have been translated into multicomponent vaccines …
Acquisition of antibodies against Plasmodium falciparum merozoites and malaria immunity in young children and the influence of age, force of infection, and …
Individuals in areas of Plasmodium falciparum endemicity develop immunity to malaria after
repeated exposure. Knowledge of the acquisition and nature of protective immune …
repeated exposure. Knowledge of the acquisition and nature of protective immune …
The future for blood‐stage vaccines against malaria
JS Richards, JG Beeson - Immunology and cell biology, 2009 - Wiley Online Library
Malaria is a leading cause of mortality and morbidity globally, and effective vaccines are
urgently needed. Malaria vaccine approaches can be broadly grouped as pre‐erythrocytic …
urgently needed. Malaria vaccine approaches can be broadly grouped as pre‐erythrocytic …
Apical membrane antigen 1, a major malaria vaccine candidate, mediates the close attachment of invasive merozoites to host red blood cells
GH Mitchell, AW Thomas, G Margos… - Infection and …, 2004 - Am Soc Microbiol
ABSTRACT Apical membrane antigen 1 (AMA-1) of Plasmodium merozoites is established
as a candidate molecule for inclusion in a human malaria vaccine and is strongly conserved …
as a candidate molecule for inclusion in a human malaria vaccine and is strongly conserved …