Cl− channels reside both in the plasma membrane and in intracellular organelles. Their
functions range from ion homeostasis to cell volume regulation, transepithelial transport, and …

Endothelial cells (EC) form a unique signal-transducing surface in the vascular system. The
abundance of ion channels in the plasma membrane of these nonexcitable cells has raised …

Ca 2+-permeable channels that are involved in the responses of mammalian cells to
changes in extracellular osmolarity have not been characterized at the molecular level. Here …

The volume-regulated anion channel (VRAC) is activated when a cell swells, and it plays a
central role in maintaining cell volume in response to osmotic challenges. SWELL1 …

Forced expression of gap junction proteins, connexins, enables gap junction-deficient cell
lines to propagate intercellular calcium waves. Here, we show that ATP secretion from the …

▪ Abstract Calcium-activated chloride channels (CaCCs) play important roles in cellular
physiology, including epithelial secretion of electrolytes and water, sensory transduction …

The formation of vascular lumens by endothelial cells is a critical step in the angiogenic
process that occurs during invasion and growth of the incipient vascular sprout. Once a …

Growth of collateral blood vessels (arteriogenesis) is potentially able to preserve structure
and function of limbs and organs after occlusion of a major artery. The success of the …

Growth of collateral vessels is potentially able to preserve structure and a variable degree of
function in subtended tissues in the presence of arterial occlusions. The process of …

Aim: This review describes molecular and functional properties of the following Cl–channels:
the ClC family of voltage‐dependent Cl–channels, the cAMP‐activated transmembrane …