Utilizing graph machine learning within drug discovery and development
Graph machine learning (GML) is receiving growing interest within the pharmaceutical and
biotechnology industries for its ability to model biomolecular structures, the functional …
biotechnology industries for its ability to model biomolecular structures, the functional …
In silico analysis of epitope-based vaccine candidate against tuberculosis using reverse vaccinology
Tuberculosis (TB) kills more individuals in the world than any other disease, and a threat
made direr by the coverage of drug-resistant strains of Mycobacterium tuberculosis (Mtb) …
made direr by the coverage of drug-resistant strains of Mycobacterium tuberculosis (Mtb) …
Management of Mycobacterium avium complex and Mycobacterium abscessus pulmonary disease: therapeutic advances and emerging treatments
K Kumar, CL Daley, DE Griffith… - European Respiratory …, 2022 - Eur Respiratory Soc
Nontuberculous mycobacterial pulmonary disease (NTM-PD) remains a challenging
condition to diagnose and treat effectively. Treatment of NTM-PD is prolonged, frequently …
condition to diagnose and treat effectively. Treatment of NTM-PD is prolonged, frequently …
Mycobacterium abscessus pathogenesis identified by phenogenomic analyses
L Boeck, S Burbaud, M Skwark, WH Pearson… - Nature …, 2022 - nature.com
The medical and scientific response to emerging and established pathogens is often
severely hampered by ignorance of the genetic determinants of virulence, drug resistance …
severely hampered by ignorance of the genetic determinants of virulence, drug resistance …
SARS-CoV-2 3D database: understanding the coronavirus proteome and evaluating possible drug targets
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a rapidly growing
infectious disease, widely spread with high mortality rates. Since the release of the SARS …
infectious disease, widely spread with high mortality rates. Since the release of the SARS …
Computational approaches in epitope design using DNA binding proteins as vaccine candidate in Mycobacterium tuberculosis
Mycobacterium tuberculosis (Mtb) is a successful pathogen in the history of mankind. A high
rate of mortality and morbidity raises the need for vaccine development. Mechanism of …
rate of mortality and morbidity raises the need for vaccine development. Mechanism of …
Genomics, computational biology and drug discovery for mycobacterial infections: fighting the emergence of resistance
Tuberculosis (TB) and leprosy are mycobacterial infections caused by Mycobacterium
tuberculosis and Mycobacterium leprae respectively. These diseases continue to be …
tuberculosis and Mycobacterium leprae respectively. These diseases continue to be …
Enhancing tuberculosis vaccine development: a deconvolution neural network approach for multi-epitope prediction
Tuberculosis (TB) a disease caused by Mycobacterium tuberculosis (Mtb) poses a
significant threat to human life, and current BCG vaccinations only provide sporadic …
significant threat to human life, and current BCG vaccinations only provide sporadic …
Emerging opportunities of exploiting mycobacterial electron transport chain pathway for drug-resistant tuberculosis drug discovery
Introduction: Tuberculosis (TB) is a leading infectious disease worldwide whose
chemotherapy is challenged by the continued rise of drug resistance. This epidemic urges …
chemotherapy is challenged by the continued rise of drug resistance. This epidemic urges …
Mycobacterium abscessus: insights from a bioinformatic perspective
S Sur, T Patra, M Karmakar… - Critical Reviews in …, 2023 - Taylor & Francis
Mycobacterium abscessus is a nontuberculous mycobacterium, associated with broncho-
pulmonary infections in individuals suffering from cystic fibrosis, bronchiectasis, and …
pulmonary infections in individuals suffering from cystic fibrosis, bronchiectasis, and …