The kainic acid model of temporal lobe epilepsy has greatly contributed to the
understanding of the molecular, cellular and pharmacological mechanisms underlying …

Experimental models of epilepsy are useful to identify potential mechanisms of
epileptogenesis, seizure genesis, comorbidities, and treatment efficacy. The kainic acid (KA) …

In order to understand the pathophysiology of temporal lobe epilepsy (TLE), and thus to
develop new pharmacological treatments, in vivo animal models that present features …

N-Methyl-d-Aspartate Receptors (NMDARs) are ionotropic glutamate-gated receptors.
NMDARs are tetramers composed by several homologous subunits of GluN1-, GluN2-, or …

Epilepsy is a group of neurological disorders commonly associated with the neuronal
malfunction leading to generation of seizures. Recent reports point to a possible contribution …

Episodic memory deficit is a common cognitive disorder in human temporal lobe epilepsy
(TLE). However, no animal model of TLE has been shown to specifically replicate this …

There has been a major emphasis on defining the role of seizures in the causation of
cognitive impairments like memory deficits in epilepsy. Here we focus on an alternative …

Cognitive deficits and memory loss are frequent in patients with temporal lobe epilepsy.
Persistent changes in synaptic efficacy are considered as a cellular substrate underlying …

Here we describe a novel mouse model of temporal lobe epilepsy (TLE) that moves the site
of kainate injection from the rodent dorsal hippocampus (corresponding to the human …

It is well known that physical exercise has positive effects on cognitive functions and
hippocampal plasticity. However, the underlying mechanisms have remained to be further …