Glycosylation is the most abundant and diverse form of post-translational modification of
proteins that is common to all eukaryotic cells. Enzymatic glycosylation of proteins involves a …

Congenital disorders of glycosylation (CDG) are a rapidly expanding group of metabolic
disorders that result from abnormal protein or lipid glycosylation. They are often difficult to …

The spatial organization of chromosomes influences many nuclear processes including
gene expression. The cohesin complex shapes the 3D genome by looping together CTCF …

Although the genes essential for life have been identified in less complex model organisms,
their elucidation in human cells has been hindered by technical barriers. We used extensive …

There is an urgent need for vaccines and therapeutics to prevent and treat COVID-19. Rapid
SARS-CoV-2 countermeasure development is contingent on the availability of robust …

Large-scale genetic analysis of lethal phenotypes has elucidated the molecular
underpinnings of many biological processes. Using the bacterial clustered regularly …

The structural diversity of glycans on cells—the glycome—is vast and complex to decipher.
Glycan arrays display oligosaccharides and are used to report glycan hapten binding …

As noted by Warburg, many cancer cells depend on the consumption of glucose. We
performed a genetic screen to identify factors responsible for glucose addiction and …

The existence of extracellular phosphoproteins has been acknowledged for over a century.
However, research in this area has been undeveloped largely because the kinases that …

Near-haploid human cell lines are instrumental for genetic screens and genome
engineering as gene inactivation is greatly facilitated by the absence of a second gene copy …