Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Cellular stress induced by the abnormal accumulation of unfolded or misfolded proteins at
the endoplasmic reticulum (ER) is emerging as a possible driver of human diseases …

The clinical manifestation of neurodegenerative diseases is initiated by the selective
alteration in the functionality of distinct neuronal populations. The pathology of many …

The Caenorhabditis elegans genome possesses homologs of about two-thirds of all human
disease genes. Based on its physiological aging characteristics and superiority, the use of …

Initiating and maintaining optimal immune responses requires high levels of protein
synthesis, folding, modification and trafficking in leukocytes, which are processes …

Human mesenchymal stem cells (MSCs) are primary multipotent cells capable of
differentiating into osteocytes, chondrocytes, and adipocytes when stimulated under …

Abstract Growth differentiation factor 15 (GDF15) is recently emerging not only as a stress-
related mitokine, but also as a key player in the aging process, being one of the most up …

Endoplasmic reticulum (ER) stress is associated with development and progression of
fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). ER stress was first implicated …

The ageing of the global population brings about unprecedented challenges. Chronic age‐
related diseases in an increasing number of people represent an enormous burden for …

ABSTRACT BACKGROUND The unbalanced transmission of chromosomes in human
gametes and early preimplantation embryos causes aneuploidy, which is a major cause of …