Introduction 3. The kynurenine pathway and de novo NAD biosynthesis 3.1. ACMS
decarboxylase diverts the kynurenine pathway from NAD synthesis 3.2. Quinolinate …

The addiction of tumors to elevated nicotinamide adenine dinucleotide (NAD+) levels is a
hallmark of cancer metabolism. Obstructing NAD+ biosynthesis in tumors is a new and …

Enzymes involved in the last 2 steps of nicotinamide adenine dinucleotide (NAD) cofactor
biosynthesis, which catalyze the adenylylation of the nicotinic acid mononucleotide (NaMN) …

Streptococcal pathogens contribute to a wide variety of human and livestock diseases. The
routine use of antibiotics to battle these pathogens has produced a new class of multidrug …

NAD is a ubiquitous and essential metabolic redox cofactor which also functions as a
substrate in certain regulatory pathways. The last step of NAD synthesis is the ATP …

The Streptomyces coelicolor A3 (2) gene SCI11. 14c was overexpressed and purified as a
His-tagged protein from heterologous host, Streptomyces lividans. The purification …

NAD (P) biosynthetic pathways can be considered a generous source of enzymatic targets
for drug development. Key reactions for NAD (P) biosynthesis in all organisms, common to …

NAD (P) is an indispensable cofactor for all organisms and its biosynthetic pathways are
proposed as promising novel antibiotics targets against pathogens such as Mycobacterium …

Nicotinamide adenine dinucleotide (NAD+) synthetase catalyzes the last step in NAD+
biosynthesis. Depletion of NAD+ is bactericidal for both active and dormant Mycobacterium …

Virtual screening was employed to identify new drug-like inhibitors of NAD synthetase
(NADs) as antibacterial agents. Four databases of commercially available compounds were …