IMI–Report on experimental models of emmetropization and myopia

D Troilo, EL Smith, DL Nickla, R Ashby… - … & visual science, 2019 - iovs.arvojournals.org
The results of many studies in a variety of species have significantly advanced our
understanding of the role of visual experience and the mechanisms of postnatal eye growth …

Homeostasis of eye growth and the question of myopia

J Wallman, J Winawer - Neuron, 2004 - cell.com
As with other organs, the eye's growth is regulated by homeostatic control mechanisms.
Unlike other organs, the eye relies on vision as a principal input to guide growth. In this …

The influence of the choroid on the onset and development of myopia: from perspectives of choroidal thickness and blood flow

Y Liu, L Wang, Y Xu, Z Pang, G Mu - Acta Ophthalmologica, 2021 - Wiley Online Library
Myopia is the most common type of refractive errors characterized by excessive elongation
of the ocular globe. With the increasing prevalence of myopia, improved knowledge of …

Choroidal changes in human myopia: insights from optical coherence tomography imaging

SA Read, JA Fuss, SJ Vincent, MJ Collins… - Clinical and …, 2019 - Taylor & Francis
The choroid is a vascular tissue which plays a range of critical roles in the normal physiology
of the eye, such as supplying the outer retina with oxygen and nutrients and the regulation of …

The sclera and myopia

JAS Rada, S Shelton, TT Norton - Experimental eye research, 2006 - Elsevier
Myopia is a very common ocular problem, affecting perhaps one billion people worldwide.
Most myopia is produced by lengthening of the vitreous chamber of the ocular globe. High …

[HTML][HTML] Peripheral vision can influence eye growth and refractive development in infant monkeys

EL Smith, C Kee, R Ramamirtham… - … & visual science, 2005 - arvojournals.org
purpose. Given the prominence of central vision in humans, it has been assumed that visual
signals from the fovea dominate emmetropization. The purpose of this study was to examine …

The dynamic sclera: extracellular matrix remodeling in normal ocular growth and myopia development

AR Harper, JA Summers - Experimental eye research, 2015 - Elsevier
Myopia is a common ocular condition, characterized by excessive elongation of the ocular
globe. The prevalence of myopia continues to increase, particularly among highly educated …

[HTML][HTML] The role of optical defocus in regulating refractive development in infant monkeys

EL Smith III, LF Hung - Vision research, 1999 - Elsevier
Early in life, the two eyes of infant primates normally grow in a coordinated manner toward
the ideal refractive state. We investigated the extent to which lens-induced changes in the …

[HTML][HTML] IMI—the dynamic choroid: new insights, challenges, and potential significance for human myopia

LA Ostrin, E Harb, DL Nickla, SA Read… - … & visual science, 2023 - jov.arvojournals.org
The choroid is the richly vascular layer of the eye located between the sclera and Bruch's
membrane. Early studies in animals, as well as more recent studies in humans, have …

[HTML][HTML] Structural and ultrastructural changes to the sclera in a mammalian model of high myopia

NA McBrien, LM Cornell… - … ophthalmology & visual …, 2001 - jov.arvojournals.org
purpose. The development of high myopia is associated with scleral thinning and changes
in the diameter of scleral collagen fibrils in humans. In the present study, the association …