The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …

Stem cell niches are specialized microenvironments that promote the maintenance of stem
cells and regulate their function. Recent advances have improved our understanding of the …

MicroRNAs (miRNAs) are crucial post-transcriptional regulators of haematopoietic cell fate
decisions. They act by negatively regulating the expression of key immune development …

Little is known about how leukemia cells alter the bone marrow (BM) niche to facilitate their
own growth and evade chemotherapy. Here, we provide evidence that acute myeloid …

A central function of the vascular endothelium is to serve as a barrier between the blood and
the surrounding tissue of the body. At the same time, solutes and cells have to pass the …

Circular RNAs (circRNAs) have emerged as pivotal regulators of gene expression and
cellular processes in various physiological and pathological conditions. In recent years …

Hematopoietic stem cells (HSCs) rely on instructive cues from the bone marrow (BM) niche
to maintain their quiescence and adapt blood production to the organism's needs …

Germline activating mutations of the protein tyrosine phosphatase SHP2 (encoded by
PTPN11), a positive regulator of the RAS signalling pathway, are found in 50% of patients …

The surface of endothelial cells is covered with cell adhesion molecules, including E‐
selectin, intercellula adhesion molecule 1 (ICAM‐1), and vascular cell adhesion molecule 1 …

The bone marrow microenvironment contains a heterogeneous population of stromal cells
organized into niches that support hematopoietic stem cells (HSCs) and other lineage …