Histone lysine methylations have primarily been linked to selective recruitment of reader or
effector proteins that subsequently modify chromatin regions and mediate genome functions …

Monomethylation of lysine 20 of histone H4 (H4K20me1) is catalyzed by Set8 and thought to
play important roles in many aspects of genome function that are mediated by H4K20me …

During X chromosome inactivation (XCI), in female placental mammals, gene silencing is
initiated by the Xist long non‐coding RNA. Xist accumulation at the X leads to enrichment of …

Circadian rhythms, essential 24-hour cycles guiding biological functions, synchronize
organisms with daily environmental changes. These rhythms, which are evolutionarily …

Recurrent miscarriage (RM) is a distressing pregnancy complication. While the etiology of
RM remains unclear, growing evidence has indicated the relevance of trophoblast …

Immunotherapy has become established as major treatment modality for multiple types of
solid tumors, including colorectal cancer. Identifying novel immunotherapeutic targets to …

Triple-negative breast cancer (TNBC) is the most difficult breast cancer subtype to treat due
to the lack of targeted therapies. Cancer stem cells (CSCs) are strongly enriched in TNBC …

The regulation of hepatic gene expression has been extensively studied at the
transcriptional level; however, the control of metabolism through posttranscriptional gene …

Non-alcoholic fatty liver disease (NAFLD) poses a significant health challenge in modern
societies due to shifts in lifestyle and dietary habits. Its complexity stems from genetic …

Hepatocellular carcinoma (HCC) is one of the most aggressive cancers worldwide. Despite
such a public health importance, efficient therapeutic agents are still lacking for this …