The role of GABAA receptors in the acute and chronic effects of ethanol: a decade of progress

S Kumar, P Porcu, DF Werner, DB Matthews… - …, 2009 - Springer
The past decade has brought many advances in our understanding of GABA A receptor-
mediated ethanol action in the central nervous system. We now know that specific GABA A …

The space where aging acts: Focus on the GABA ergic synapse

A Rozycka, M Liguz‐Lecznar - Aging cell, 2017 - Wiley Online Library
As it was established that aging is not associated with massive neuronal loss, as was
believed in the mid‐20th Century, scientific interest has addressed the influence of aging on …

An update on GABAA receptors

AK Mehta, MK Ticku - Brain research reviews, 1999 - Elsevier
Recent advances in molecular biology and complementary information derived from
neuropharmacology, biochemistry and behavior have dramatically increased our …

Role of brain allopregnanolone in the plasticity of γ-aminobutyric acid type A receptor in rat brain during pregnancy and after delivery

A Concas, MC Mostallino, P Porcu… - Proceedings of the …, 1998 - National Acad Sciences
The relation between changes in brain and plasma concentrations of neurosteroids and the
function and structure of γ-aminobutyric acid type A (GABAA) receptors in the brain during …

GABAA receptors in aging and Alzheimer's disease

RA Rissman, AL De Blas… - Journal of …, 2007 - Wiley Online Library
In this article we present a comprehensive review of relevant research and reports on the
GABAA receptor in the aged and Alzheimer's disease (AD) brain. In comparison to …

Drug dosage in the elderly: is it rational?

K Turnheim - Drugs & aging, 1998 - Springer
Pharmacotherapy in the elderly requires an understanding of the age-dependent changes in
function and composition of the body. Aging is characterised by a progressive loss of …

Changes in neocortical and hippocampal GABAA receptor subunit distribution during brain maturation and aging

ZY Yu, W Wang, JM Fritschy, OW Witte, C Redecker - Brain research, 2006 - Elsevier
γ-Aminobutyric acid type A (GABAA) receptors are the most important inhibitory receptors in
the central nervous system, playing a pivotal role in the regulation of brain excitability. The …

Functional degradation of visual cortical cells in old cats

T Hua, X Li, L He, Y Zhou, Y Wang, AG Leventhal - Neurobiology of aging, 2006 - Elsevier
Visual function declines with age. Using extracellular single-unit in vivo recordings, we
compared the function of primary visual cortical (area 17) cells in young and old paralyzed …

Age-related changes in GABAA receptor subunit composition and function in rat auditory system

DM Caspary, TM Holder, LF Hughes, JC Milbrandt… - Neuroscience, 1999 - Elsevier
A decline in the ability to discriminate speech from noise due to age-related hearing loss
(presbycusis) may reflect impaired auditory information processing within the central …

Decreased proportion of GABA neurons accompanies age-related degradation of neuronal function in cat striate cortex

T Hua, C Kao, Q Sun, X Li, Y Zhou - Brain research bulletin, 2008 - Elsevier
Electrophysiological studies indicate that a decline of GABAergic inhibition in the visual
cortex may underlie age-related degradation of visual function [AG Leventhal, Y. Wang, M …