The molecular mechanisms by which microtubule-associated proteins (MAPs) regulate the
dynamic properties of microtubules (MTs) are still poorly understood. We review recent …

The budding and fission yeasts Saccharomyces cerevisiae and Schizosaccharomyces
pombe have served as invaluable model organisms to study conserved fundamental cellular …

The organization and number of microtubules (MTs) in a cell depend on the proper
regulation of MT nucleation. Currently, the mechanism of nucleation is the most poorly …

XMAP215/Dis1 proteins are conserved tubulin-binding TOG-domain proteins that regulate
microtubule (MT) plus-end dynamics. Here we show that Alp14, a XMAP215 orthologue in …

Cytoplasmic dynein is the predominant minus-end-directed microtubule (MT) motor in most
eukaryotic cells. In addition to transporting vesicular cargos, dynein helps to organize MTs …

Within the mitotic spindle, kinesin motors cross-link and slide overlapping microtubules.
Some of these motors exhibit off-axis power strokes, but their impact on motility and force …

An organised spindle is crucial to the fidelity of chromosome segregation, but the
relationship between spindle structure and function is not well understood in any cell type …

Mitotic spindle function depends on the precise regulation of microtubule dynamics and
microtubule sliding. Throughout mitosis, both processes have to be orchestrated to establish …

Antiparallel microtubule bundles are essential structural elements of many cytoskeletal
structures, for instance, the mitotic spindle. Sliding of microtubules relative to each other can …

The shortening of microtubules attached to kinetochores is the driving force of chromosome
movement during cell division. Specific kinesins are believed to shorten microtubules but …