Breastfeeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers
J Kotsopoulos, J Lubinski, L Salmena, HT Lynch… - Breast cancer …, 2012 - Springer
Introduction Breastfeeding has been inversely related to breast cancer risk in the general
population. Clarifying the role of breastfeeding among women with a BRCA1 or BRCA2 …
population. Clarifying the role of breastfeeding among women with a BRCA1 or BRCA2 …
BRCA1 16 years later: risk‐associated BRCA1 mutations and their functional implications
RJ Linger, PA Kruk - The FEBS journal, 2010 - Wiley Online Library
Mutations in the tumor suppressor breast cancer susceptibility gene 1 (BRCA1), an
important player in the DNA damage response, apoptosis, cell cycle regulation and …
important player in the DNA damage response, apoptosis, cell cycle regulation and …
BRCA1 16 years later: DNA damage‐induced BRCA1 shuttling
ES Yang, F Xia - The FEBS journal, 2010 - Wiley Online Library
The tumor suppressor, breast cancer susceptibility gene 1 (BRCA1), plays an integral role in
the maintenance of genome stability and, in particular, the cellular response to DNA …
the maintenance of genome stability and, in particular, the cellular response to DNA …
Erlotinib attenuates homologous recombinational repair of chromosomal breaks in human breast cancer cells
The epidermal growth factor receptor (EGFR) family has been implicated in several cancers,
including breast, and its members have become the target of novel cancer therapies. In this …
including breast, and its members have become the target of novel cancer therapies. In this …
DNA damage induces p53-dependent BRCA1 nuclear export
Z Feng, L Kachnic, J Zhang, SN Powell, F Xia - Journal of Biological …, 2004 - ASBMB
The tumor suppressor gene BRCA1 plays an important role in the response to DNA
damage. BRCA1 function is regulated by a variety of mechanisms including transcriptional …
damage. BRCA1 function is regulated by a variety of mechanisms including transcriptional …
BARD1 regulates BRCA1 apoptotic function by a mechanism involving nuclear retention
M Fabbro, S Schuechner, WWY Au… - Experimental cell …, 2004 - Elsevier
BRCA1 is involved in maintaining genomic integrity and, as a regulator of the G2/M
checkpoint, contributes to DNA repair and cell survival. The overexpression of BRCA1 elicits …
checkpoint, contributes to DNA repair and cell survival. The overexpression of BRCA1 elicits …
DNA Damage–Induced Cytotoxicity Is Dissociated from BRCA1's DNA Repair Function but Is Dependent on Its Cytosolic Accumulation
The tumor suppressor BRCA1 is a nuclear shuttling protein. However, the role of BRCA1
localization in the control of its functions remains to be elucidated. Given the central role of …
localization in the control of its functions remains to be elucidated. Given the central role of …
The Icelandic founder mutation BRCA2 999del5: analysis of expression
EK Mikaelsdottir, S Valgeirsdottir, JE Eyfjord… - Breast Cancer …, 2004 - Springer
Introduction A founder mutation in the BRCA2 gene (BRCA2 999del5) accounts for 7–8% of
female breast cancers and for 40% of male breast cancers in Iceland. If expressed, the …
female breast cancers and for 40% of male breast cancers in Iceland. If expressed, the …
Disruption of BRCA1 function results in telomere lengthening and increased anaphase bridge formation in immortalized cell lines
JD French, J Dunn, CE Smart… - Genes …, 2006 - Wiley Online Library
BRCA1 is a tumor suppressor that functions in controlling cell growth and maintaining
genomic stability. BRCA1 has also been implicated in telomere maintenance through its …
genomic stability. BRCA1 has also been implicated in telomere maintenance through its …
BRCA1 haploinsufficiency, but not heterozygosity for a BRCA1-truncating mutation, deregulates homologous recombination
I Cousineau, A Belmaaza - Cell Cycle, 2007 - Taylor & Francis
Humans heterozygous for BRCA1 mutations have a high risk of losing the remaining wild-
type BRCA1 allele and developing breast/ovarian cancer, but a molecular basis for this has …
type BRCA1 allele and developing breast/ovarian cancer, but a molecular basis for this has …