Affinity chromatography (AC) has been used in large‐scale bioprocessing for almost 40
years and is considered the preferred method for primary capture in downstream processing …

Solid phase screenings of one bead one compound (OBOC) libraries have been widely
used to find ligands with pharmacological and analytical uses, and to purify or detect …

The discovery of peptides possessing high biological activity is very challenging due to the
enormous diversity for which only a minority have the desired properties. To lower cost and …

Erythropoietin (EPO) is a heavily glycosylated hormone whose recombinant forms are used
for treatment of anaemia. EPO glycosylation is important for its pharmacological properties …

Prior work described the identification and characterization of erythropoietin-binding cyclic
peptides SLFFLH, VVFFVH, FSLLHH and FSLLSH (all of the form cyclo [(N α-Ac) Dap (A)-X …

The interest in therapeutic monoclonal antibodies (mAbs) has significantly grown in the
pharmaceutical industry, exceeding 100 FDA mAbs approved. Although the upstream …

The rapid increase in antibody demand is urgently calling for high throughput technologies
to enhance the efficiency in downstream purification. Membrane chromatography using …

This work presents the selection and characterization of erythropoietin (EPO)-binding cyclic
peptide ligands. The sequences were selected by screening a focused library of cyclic …

Cognitive impairment is the only indicator of growing Alzheimer's disease (AD), which may
cause dementia. There is no cure or effective treatment to prevent deep AD progression …

Recombinant human erythropoietin is a valuable therapeutic protein used in the treatment of
several serious diseases. It exists in different isoforms and is produced by genetically …