Methods Clinical practice guidelines for TDM of VCM were reviewed by a practice guideline
committee that consisted of 18 experts in TDM convened from the JSC and the JSTDM. The …

Importance Staphylococcus aureusbacteremia (SAB) in children causes significant morbidity
and mortality, but the epidemiology in children is not well characterized. Objective To …

Antimicrobials and antivirals are widely used in young infants and neonates. These patients
have historically been largely excluded from clinical trials and, as a consequence, the …

Vancomycin area under the curve/minimal inhibitory concentration (AUC/MIC)> 400 best
predicts the outcome when treating invasive methicillin-resistant Staphylococcus aureus …

Background Limited studies incorporating population-based pharmacokinetic modeling
have been conducted to determine pharmacodynamic indices associated with …

Objectives To develop a population pharmacokinetic (PK) model for vancomycin in Chinese
neonates and infants less than 2 months of age (young infants) with a wide gestational age …

Background Vancomycin is a common drug used in children with severe infection. In adults,
at least 15 mg/L of the optimal vancomycin trough concentration (C trough) is needed to …

Background Vancomycin treatment failure has been associated with low serum vancomycin
trough concentrations, prompting recommendations to increase the daily doses in adults …

Abstract Background/Purpose The aim of this study is to determine the best dosing strategy
for vancomycin by studying the associated factors and examining correlations between the …

The 24‐hour vancomycin area under the serum concentration‐time curve (AUC24) divided
by the minimum inhibitory concentration (MIC)(AUC24/MIC) is more closely related to patient …