Intranasal delivery of mitochondria targeted neuroprotective compounds for traumatic brain injury: screening based on pharmacological and physiological properties
Targeting drugs to the mitochondrial level shows great promise for acute and chronic
treatment of traumatic brain injury (TBI) in both military and civilian sectors. Perhaps the …
treatment of traumatic brain injury (TBI) in both military and civilian sectors. Perhaps the …
Aberrant ER stress induced neuronal-IFNβ elicits white matter injury due to microglial activation and T-cell infiltration after TBI
Persistent endoplasmic reticulum (ER) stress in neurons is associated with activation of
inflammatory cells and subsequent neuroinflammation following traumatic brain injury (TBI); …
inflammatory cells and subsequent neuroinflammation following traumatic brain injury (TBI); …
Repeated mild traumatic brain injuries perturb the mitochondrial biogenesis via DNA methylation in the hippocampus of rat
Mitochondrial biogenesis in the brain is impaired in various neurological disorders including
traumatic brain injury (TBI). The long-lasting effects of TBI may be, in part, attributed to …
traumatic brain injury (TBI). The long-lasting effects of TBI may be, in part, attributed to …
[HTML][HTML] Formoterol, a β2-adrenoreceptor agonist, induces mitochondrial biogenesis and promotes cognitive recovery after traumatic brain injury
Traumatic brain injury (TBI) leads to acute necrosis at the site of injury followed by a
sequence of secondary events lasting from hours to weeks and often years. Targeting …
sequence of secondary events lasting from hours to weeks and often years. Targeting …
An augmentation in histone dimethylation at lysine nine residues elicits vision impairment following traumatic brain injury
Abstract Traumatic Brain Injury (TBI) affects more than 1.7 million Americans each year and
about 30% of TBI-patients having visual impairments. The loss of retinal ganglion cells …
about 30% of TBI-patients having visual impairments. The loss of retinal ganglion cells …
Histone deacetylase 4 downregulation elicits post-traumatic psychiatric disorders through impairment of neurogenesis
An enduring deficit in neurogenesis largely contributes to the development of severe post-
traumatic psychiatric disorders such as anxiety, depression, and memory impairment …
traumatic psychiatric disorders such as anxiety, depression, and memory impairment …
Schisandrin restores the amyloid β-induced impairments on mitochondrial function, energy metabolism, biogenesis, and dynamics in rat primary hippocampal neurons
Z Piao, L Song, L Yao, L Zhang, Y Lu - Pharmacology, 2021 - karger.com
Introduction: Schisandrin which is derived from Schisandra chinensis has shown multiple
pharmacological effects on various diseases including Alzheimer's disease (AD). It is …
pharmacological effects on various diseases including Alzheimer's disease (AD). It is …
[HTML][HTML] Understanding the link between traumatic brain injury and Alzheimer's disease
B Lucke-Wold - Annals of translational medicine, 2018 - ncbi.nlm.nih.gov
Due to the multitude of failed clinical trials for neurodegenerative diseases, many prominent
researchers have begun to reexamine what we know about these diseases and how they …
researchers have begun to reexamine what we know about these diseases and how they …
Aberrant cell cycle induction is pivotal for mitochondrial biogenesis after traumatic brain injury
N Sen - Neural Regeneration Research, 2019 - journals.lww.com
Cell cycle regulation and brain injury: Traumatic brain injury (TBI) is one of the primary
causes of morbidity and mortality in patients, and it affects more than 1.7 million Americans …
causes of morbidity and mortality in patients, and it affects more than 1.7 million Americans …
Mitochondrial dysfunction in traumatic brain injury: management strategies
CA Bonilla-Mendoza, E Garcia-Ballestas… - Indian Journal of …, 2020 - thieme-connect.com
Today, traumatic brain injuries continue to be studied, increasingly investigating the
pathophysiological mechanisms that contribute to the clinical presentation, severity, and …
pathophysiological mechanisms that contribute to the clinical presentation, severity, and …