[HTML][HTML] Oxidative stress and inflammation in the pathogenesis of neurological disorders: Mechanisms and implications

UC Dash, NK Bhol, SK Swain, RR Samal… - … Pharmaceutica Sinica B, 2024 - Elsevier
Neuroprotection is a proactive approach to safeguarding the nervous system, including the
brain, spinal cord, and peripheral nerves, by preventing or limiting damage to nerve cells …

The involvement of neuroinflammation in the onset and progression of Parkinson's disease

A Jurcau, FL Andronie-Cioara… - International Journal of …, 2023 - mdpi.com
Parkinson's disease is a neurodegenerative disease exhibiting the fastest growth in
incidence in recent years. As with most neurodegenerative diseases, the pathophysiology is …

Alzheimer disease as a clinical-biological construct—an International Working Group recommendation

B Dubois, N Villain, L Schneider, N Fox… - JAMA …, 2024 - jamanetwork.com
Importance Since 2018, a movement has emerged to define Alzheimer disease (AD) as a
purely biological entity based on biomarker findings. The recent revision of the Alzheimer's …

Anti-Alzheimers molecular mechanism of icariin: insights from gut microbiota, metabolomics, and network pharmacology

Y Liu, H Li, X Wang, J Huang, D Zhao, Y Tan… - Journal of translational …, 2023 - Springer
Background Icariin (ICA), an active ingredient extracted from Epimedium species, has
shown promising results in the treatment of Alzheimer's disease (AD), although its potential …

Alzheimer's disease: combination therapies and clinical trials for combination therapy development

JL Cummings, AML Osse, JW Kinney, D Cammann… - CNS drugs, 2024 - Springer
Alzheimer's disease (AD) is a complex multifaceted disease. Recently approved anti-
amyloid monoclonal antibodies slow disease progression by approximately 30%, and …

[HTML][HTML] Inflammaging and Brain Aging

MC Jurcau, A Jurcau, A Cristian, VO Hogea… - International Journal of …, 2024 - mdpi.com
Progress made by the medical community in increasing lifespans comes with the costs of
increasing the incidence and prevalence of age-related diseases, neurodegenerative ones …

Alzheimer's disease treatment: the search for a breakthrough

AB Reiss, D Muhieddine, B Jacob, M Mesbah… - Medicina, 2023 - mdpi.com
As the search for modalities to cure Alzheimer's disease (AD) has made slow progress,
research has now turned to innovative pathways involving neural and peripheral …

Implicative role of cytokines in neuroinflammation mediated AD and associated signaling pathways: Current progress in molecular signaling and therapeutics

S Kumari, R Dhapola, P Sharma, SK Singh… - Ageing Research …, 2023 - Elsevier
Alzheimer's Disease (AD) is one of the most devastating age-related disorder causing
significant social and economic burden worldwide. It affects the cognitive and social …

[HTML][HTML] NOX-induced oxidative stress is a primary trigger of major neurodegenerative disorders

Y Zilberter, DR Tabuena, M Zilberter - Progress in Neurobiology, 2023 - Elsevier
Neurodegenerative diseases (NDDs) causing cognitive impairment and dementia are
difficult to treat due to the lack of understanding of primary initiating factors. Meanwhile …

Folic acid improved memory and learning function in a rat model of neuroinflammation induced by lipopolysaccharide

ZK Darbandi, S Amirahmadi, I Goudarzi… - …, 2024 - Springer
Folic acid (FA) plays an important role in the maintenance of normal neurological functions
such as memory and learning function. Neuroinflammation contributes to the progression of …