The intensive study and investigation of neuroprotective therapy for central nervous system
(CNS) diseases is ongoing. Due to shared mechanisms of neurodegeneration, a …

Cerebral stroke is a pressing global health concern, ranking as the second leading cause of
mortality and resulting in persistent neurobehavioral impairments. Cerebral strokes …

Mutations of the Na+-activated K+ channel Slack (KCNT1) are associated with terrible
epilepsy syndromes that already begin in infancy. Here we report increased severity of acute …

Mutations of large conductance Ca2+-and voltage-activated K+ channels (BK) are
associated with cognitive impairment. Here we report that CA1 pyramidal neuron-specific …

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by
impaired social interaction and restricted, repetitive behavior. Multiple studies have …

Abstract Aims Na+-activated Slack potassium (K+) channels are increasingly recognized as
regulators of neuronal activity, yet little is known about their role in the cardiovascular …

Neuronal activity is accompanied by a net outflow of potassium ions (K+) from the intra-to the
extracellular space. While extracellular [K+] changes during neuronal activity are well …

Quinidine has been used as an anticonvulsant to treat patients with KCNT1-related epilepsy
by targeting gain-of-function KCNT1 pathogenic mutant variants. However, the detailed …

Human mutations of the Na+-activated K+ channel Slack (KCNT1) are associated with
epilepsy and intellectual disability. Accordingly, Slack knockout mice (Slack−/−) exhibit …

Epilepsy, a widespread neurological disorder, affects approximately 50 million people
worldwide. This disorder is typified by recurring seizures due to abnormal neuron …