Spinal cord injury: molecular mechanisms and therapeutic interventions

X Hu, W Xu, Y Ren, Z Wang, X He, R Huang… - Signal transduction and …, 2023 - nature.com
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …

Spinal cord atrophy after spinal cord injury–A systematic review and meta-analysis

C Trolle, E Goldberg, C Linnman - NeuroImage: Clinical, 2023 - Elsevier
Cervical spinal cord atrophy occurs after spinal cord injury. The atrophy and how level of
injury affects atrophy differs between studies. A systematic review and metaanalysis were …

[HTML][HTML] Reliability of multi-parameter mapping (MPM) in the cervical cord: A multi-center multi-vendor quantitative MRI study

M Seif, T Leutritz, S Schading, T Emmengger, A Curt… - Neuroimage, 2022 - Elsevier
MRI based multicenter studies which target neurological pathologies affecting the spinal
cord and brain–including spinal cord injury (SCI)–require standardized acquisition protocols …

Remodeling of the brain correlates with gait instability in cervical spondylotic myelopathy

X Wu, Y Wang, J Chang, K Zhu, S Zhang, Y Li… - Frontiers in …, 2023 - frontiersin.org
Introduction Cervical spondylotic myelopathy (CSM) is a common form of non-traumatic
spinal cord injury (SCI) and usually leads to remodeling of the brain and spinal cord. In CSM …

Improving diagnostic workup following traumatic spinal cord injury: advances in biomarkers

S Schading, TM Emmenegger, P Freund - Current neurology and …, 2021 - Springer
Abstract Purpose of Review Traumatic spinal cord injury (SCI) is a life-changing event with
drastic implications for patients due to sensorimotor impairment and autonomous …

Degeneration of the sensorimotor tract in degenerative cervical myelopathy and compensatory structural changes in the brain

S Chen, Y Wang, X Wu, J Chang, W Jin, W Li… - Frontiers in Aging …, 2022 - frontiersin.org
Degenerative cervical myelopathy is a progressive neurodegenerative disease, that has
become increasingly prevalent in the aging population worldwide. The current study …

Microstructural plasticity in nociceptive pathways after spinal cord injury

SP Kyathanahally, M Azzarito, J Rosner… - Journal of Neurology …, 2021 - jnnp.bmj.com
Objective To track the interplay between (micro-) structural changes along the trajectories of
nociceptive pathways and its relation to the presence and intensity of neuropathic pain (NP) …

Impact of injury duration on a sensorimotor functional network in complete spinal cord injury

Y Guo, Y Ge, J Li, W Dou, Y Pan - Journal of Neuroscience …, 2022 - Wiley Online Library
Connectivity changes after spinal cord injury (SCI) appear as dynamic post‐injury
procedures. The present study aimed to investigate the alterations in the functional …

Spinal cord pathology revealed by MRI in traumatic spinal cord injury

D Pfyffer, P Freund - Current Opinion in Neurology, 2021 - journals.lww.com
Neuroimaging biomarkers reveal focal and remote cord pathology. These biomarkers show
sensitivity to the underlying disease processes and are clinically eloquent. Thus, they …

[HTML][HTML] Dynamics of progressive degeneration of major spinal pathways following spinal cord injury: A longitudinal study

S Schading, G David, TM Emmenegger, C Achim… - NeuroImage: Clinical, 2023 - Elsevier
Background Following spinal cord injury (SCI), disease processes spread gradually along
the spinal cord forming a spatial gradient with most pronounced changes located at the …