Computational Approaches to Predict Protein–Protein Interactions in Crowded Cellular Environments
Investigating protein–protein interactions is crucial for understanding cellular biological
processes because proteins often function within molecular complexes rather than in …
processes because proteins often function within molecular complexes rather than in …
[HTML][HTML] Model-driven insights into the effects of temperature on metabolism
P Wendering, Z Nikoloski - Biotechnology Advances, 2023 - Elsevier
Temperature affects cellular processes at different spatiotemporal scales, and identifying the
genetic and molecular mechanisms underlying temperature responses paves the way to …
genetic and molecular mechanisms underlying temperature responses paves the way to …
Spatial organization of hydrophobic and charged residues affects protein thermal stability and binding affinity
What are the molecular determinants of protein–protein binding affinity and whether they are
similar to those regulating fold stability are two major questions of molecular biology, whose …
similar to those regulating fold stability are two major questions of molecular biology, whose …
Electrostatic complementarity at the interface drives transient protein-protein interactions
Understanding the mechanisms driving bio-molecules binding and determining the resulting
complexes' stability is fundamental for the prediction of binding regions, which is the starting …
complexes' stability is fundamental for the prediction of binding regions, which is the starting …
Differences in the organization of interface residues tunes the stability of the SARS-CoV-2 spike-ACE2 complex
The continuous emergence of novel variants represents one of the major problems in
dealing with the SARS-CoV-2 virus. Indeed, also due to its prolonged circulation, more than …
dealing with the SARS-CoV-2 virus. Indeed, also due to its prolonged circulation, more than …
Potential of dissimilarity measure-based computation of protein thermal stability data for determining protein interactions
J Teitz, J Sander, H Sarker… - Briefings in …, 2023 - academic.oup.com
Determining the interacting proteins in multiprotein complexes can be technically
challenging. An emerging biochemical approach to this end is based on the 'thermal …
challenging. An emerging biochemical approach to this end is based on the 'thermal …
Zepyros: A webserver to evaluate the shape complementarity of protein-protein interfaces
Shape complementarity of molecular surfaces at the interfaces is a well-known characteristic
of protein-protein binding regions, and it is critical in influencing the stability of the complex …
of protein-protein binding regions, and it is critical in influencing the stability of the complex …
[HTML][HTML] DeepTM: A deep learning algorithm for prediction of melting temperature of thermophilic proteins directly from sequences
M Li, H Wang, Z Yang, L Zhang, Y Zhu - Computational and Structural …, 2023 - Elsevier
Thermally stable proteins find extensive applications in industrial production,
pharmaceutical development, and serve as a highly evolved starting point in protein …
pharmaceutical development, and serve as a highly evolved starting point in protein …
Computational evidences of a misfolding event in an aggregation‐prone light chain preceding the formation of the non‐native pathogenic dimer
Antibody light chain amyloidosis is a disorder in which protein aggregates, mainly
composed of immunoglobulin light chains, deposit in diverse tissues impairing the correct …
composed of immunoglobulin light chains, deposit in diverse tissues impairing the correct …
Compact assessment of molecular surface complementarities enhances neural network-aided prediction of key binding residues
Predicting interactions between biomolecules, such as protein-protein complexes, remains a
challenging problem. Despite the many advancements done so far, the performances of …
challenging problem. Despite the many advancements done so far, the performances of …