Unraveling the mechanistic complexity of Alzheimer's disease through systems biology
Alzheimer's disease (AD) is a complex, multifactorial disease that has reached global
epidemic proportions. The challenge remains to fully identify its underlying molecular …
epidemic proportions. The challenge remains to fully identify its underlying molecular …
[HTML][HTML] Stability and bifurcation analysis of a buckled beam via active control
In this paper, we focus on applying active control to nonlinear dynamical beam system to
eliminate its vibration. We analyzed stability using frequency-response equations and …
eliminate its vibration. We analyzed stability using frequency-response equations and …
Bifurcation analysis of a composite cantilever beam via 1: 3 internal resonance
M Sayed, AA Mousa, DY Alzaharani, IH Mustafa… - Journal of the Egyptian …, 2020 - Springer
In this paper, we study a multiple scales perturbation and numerical solution for vibrations
analysis and control of a system which simulates the vibrations of a nonlinear composite …
analysis and control of a system which simulates the vibrations of a nonlinear composite …
Modeling the Interaction between β‐Amyloid Aggregates and Choline Acetyltransferase Activity and Its Relation with Cholinergic Dysfunction through Two‐Enzyme …
The effect of β‐amyloid aggregates on activity of choline acetyltransferase (ChAT) which is
responsible for synthesizing acetylcholine (ACh) in human brain is investigated through the …
responsible for synthesizing acetylcholine (ACh) in human brain is investigated through the …
Effect of cholineacetyltransferase activity and choline recycle ratio on diffusion-reaction modeling, bifurcation and chaotic behavior of acetylcholine neurocycle and …
This paper is an extension of the previous two papers (Mustafa et al., 2009a, b) on the
modeling, simulation and analysis of bifurcation, dynamics, and chaotic characteristics of the …
modeling, simulation and analysis of bifurcation, dynamics, and chaotic characteristics of the …
Application of continuation method and bifurcation for the acetylcholine neurocycle considering partial dissociation of acetic acid
In this paper, bifurcation and chaotic behavior of the two-enzyme–two-compartment
acetylcholine (ACh) neurocycle model developed earlier (Mustafa, Elkamel, et al., 2009; …
acetylcholine (ACh) neurocycle model developed earlier (Mustafa, Elkamel, et al., 2009; …
Pharmacokinetic/pharmacodynamic modeling and simulation of the effect of medications on β-amyloid aggregates and cholinergic neurocycle
In this paper, a 10th order nonlinear pharmacokinetics/pharmacodynamics (PK/PD) model
was developed to evaluate the impact of Alzheimer's disease (AD) medications such as …
was developed to evaluate the impact of Alzheimer's disease (AD) medications such as …
Compartmental modeling and analysis of the effect of β-amyloid on acetylcholine neurocycle via choline leakage hypothesis
In this paper, the effect of β-amyloid (Aβ) oligomer aggregates on Acetylcholine (ACh)
neurocycle of human brain and its relation to Alzheimer's disease (AD) are investigated …
neurocycle of human brain and its relation to Alzheimer's disease (AD) are investigated …
Pharmacokinetics/Pharmacodynamics and Analysis of the Effect of β-Amyloid Peptide on Acetylcholine Neurocycle and Alzheimer's Disease Medications
A Awad - 2013 - uwspace.uwaterloo.ca
The brain of Alzheimer's disease (AD) is characterized by accumulations of β-amyloid
peptide aggregates which promote neurodegentartive dysfunction. Comprehensive …
peptide aggregates which promote neurodegentartive dysfunction. Comprehensive …
[PDF][PDF] Research Article Modeling the Interaction between 𝛽-Amyloid Aggregates and Choline Acetyltransferase Activity and Its Relation with Cholinergic Dysfunction …
2. It is observed that ChAT activity needs a high concentration of 𝛽-amyloid aggregates
production rate. It is found that ChAT activity is reduced significantly when neurons are …
production rate. It is found that ChAT activity is reduced significantly when neurons are …