Spectral-domain OCT measurements in Alzheimer's disease: a systematic review and meta-analysis

VTT Chan, Z Sun, S Tang, LJ Chen, A Wong, CC Tham… - Ophthalmology, 2019 - Elsevier
Topic OCT is a noninvasive tool to measure specific retinal layers in the eye. The
relationship of retinal spectral-domain (SD) OCT measurements with Alzheimer's disease …

Leveraging visual outcome measures to advance therapy development in neuroimmunologic disorders

JS Graves, FC Oertel, A Van der Walt… - Neurology …, 2021 - AAN Enterprises
The visual system offers unparalleled precision in the assessment of neuroaxonal damage.
With the majority of patients with multiple sclerosis (MS) experiencing afferent and efferent …

Optical coherence tomography reflects brain atrophy in multiple sclerosis: a four‐year study

S Saidha, O Al‐Louzi, JN Ratchford… - Annals of …, 2015 - Wiley Online Library
Objective The aim of this work was to determine whether atrophy of specific retinal layers
and brain substructures are associated over time, in order to further validate the utility of …

Optical coherence tomography segmentation reveals ganglion cell layer pathology after optic neuritis

SB Syc, S Saidha, SD Newsome, JN Ratchford, M Levy… - Brain, 2012 - academic.oup.com
Post-mortem ganglion cell dropout has been observed in multiple sclerosis; however,
longitudinal in vivo assessment of retinal neuronal layers following acute optic neuritis …

Ganglion cell loss in relation to visual disability in multiple sclerosis

SD Walter, H Ishikawa, KM Galetta, RE Sakai, DJ Feller… - Ophthalmology, 2012 - Elsevier
PURPOSE: We used high-resolution spectral-domain optical coherence tomography (SD-
OCT) with retinal segmentation to determine how ganglion cell loss relates to history of …

Visual dysfunction in multiple sclerosis correlates better with optical coherence tomography derived estimates of macular ganglion cell layer thickness than …

S Saidha, SB Syc, MK Durbin… - Multiple Sclerosis …, 2011 - journals.sagepub.com
Background: Post-mortem analyses of multiple sclerosis (MS) eyes demonstrate prominent
retinal neuronal ganglion cell layer (GCL) loss, in addition to related axonal retinal nerve …

Relationships between retinal axonal and neuronal measures and global central nervous system pathology in multiple sclerosis

S Saidha, ES Sotirchos, J Oh, SB Syc, MA Seigo… - JAMA …, 2013 - jamanetwork.com
Objective To determine the relationships between conventional and segmentation-derived
optical coherence tomography (OCT) retinal layer thickness measures with intracranial …

Aquaporin-4 IgG seropositivity is associated with worse visual outcomes after optic neuritis than MOG-IgG seropositivity and multiple sclerosis, independent of macular …

ES Sotirchos, A Filippatou… - Multiple Sclerosis …, 2020 - journals.sagepub.com
Background: Comparative studies of characteristics of optic neuritis (ON) associated with
myelin oligodendrocyte glycoprotein-IgG (MOG-ON) and aquaporin-4-IgG (AQP4-ON) …

[HTML][HTML] Optical coherence tomography (OCT): imaging the visual pathway as a model for neurodegeneration

KM Galetta, PA Calabresi, EM Frohman, LJ Balcer - Neurotherapeutics, 2011 - Elsevier
Axonal and neuronal degeneration are important features of multiple sclerosis (MS) and
other neurologic disorders that affect the anterior visual pathway. Optical coherence …

Retinal damage in multiple sclerosis disease subtypes measured by high‐resolution optical coherence tomography

T Oberwahrenbrock, S Schippling… - Multiple sclerosis …, 2012 - Wiley Online Library
Background. Optical coherence tomography (OCT) has facilitated characterisation of retinal
alterations in MS patients. Only scarce and in part conflicting data exists on different MS …