Cathepsins encompass a family of lysosomal proteases that mediate protein degradation
and turnover. Although mainly localized in the endolysosomal compartment, cathepsins are …

Cathepsin B is a cysteine protease that normally functions within acidic lysosomes for
protein degradation, but in numerous human diseases, cathepsin B translocates to the …

Reoviruses are non-enveloped viruses with a segmented double stranded RNA genome. In
humans, they are not associated with serious disease. Human reoviruses exhibit an inherent …

Cathepsin B (CatB) is a cysteine proteolytic enzyme widely expressed in various cells and
mainly located in the lysosomes. It contributes to the pathogenesis and development of …

Cathepsin B is a lysosomal protease that participates in protein degradation. However,
cathepsin B is also active under neutral pH conditions of the cytosol, nuclei, and …

Lysosomes are acidic organelles that mediate the degradation and recycling of cellular
waste materials. Damage to lysosomes can cause lysosomal membrane permeabilization …

Background We and others have reported that autophagy is induced by dengue viruses
(DVs) in various cell lines, and that it plays a supportive role in DV replication. This study …

Several studies have been performed to determine biomarkers that define the risk factors to
developing severe forms of dengue. In this study, the levels of TNF-α, IL-6, IL-1, IL-17 …

The biological and pathological functions of cathepsin B occur in acidic lysosomes and at
the neutral pH of cytosol, nuclei, and extracellular locations. Importantly, cathepsin B …

We previously reported that IL-2 deprivation induced acid sphingomyelinase-mediated
(ASM-mediated) ceramide elevation and apoptosis in an NK/T lymphoma cell line KHYG-1 …