Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia
S De Biasi, M Meschiari, L Gibellini, C Bellinazzi… - Nature …, 2020 - nature.com
The immune system of patients infected by SARS-CoV-2 is severely impaired. Detailed
investigation of T cells and cytokine production in patients affected by COVID-19 pneumonia …
investigation of T cells and cytokine production in patients affected by COVID-19 pneumonia …
The Th17 lineage: from barrier surfaces homeostasis to autoimmunity, cancer, and HIV-1 pathogenesis
The T helper 17 (Th17) cells represent a subset of CD4+ T-cells with unique effector
functions, developmental plasticity, and stem-cell features. Th17 cells bridge innate and …
functions, developmental plasticity, and stem-cell features. Th17 cells bridge innate and …
The role of defensins in HIV pathogenesis
BT Pace, AA Lackner, E Porter… - Mediators of …, 2017 - Wiley Online Library
Profound loss of CD4+ T cells, progressive impairment of the immune system, inflammation,
and sustained immune activation are the characteristics of human immunodeficiency virus‐1 …
and sustained immune activation are the characteristics of human immunodeficiency virus‐1 …
LILAC pilot study: effects of metformin on mTOR activation and HIV reservoir persistence during antiretroviral therapy
D Planas, A Pagliuzza, R Ponte, A Fert… - …, 2021 - thelancet.com
Background Chronic inflammation and residual HIV transcription persist in people living with
HIV (PLWH) receiving antiretroviral therapy (ART), thus increasing the risk of developing …
HIV (PLWH) receiving antiretroviral therapy (ART), thus increasing the risk of developing …
CD4+ T cells in HIV: A Friend or a Foe?
S Govindaraj, H Babu, S Kannanganat… - Frontiers in …, 2023 - frontiersin.org
Currently, there are approximately 38.4 million individuals living with the Human
Immunodeficiency Virus (HIV), of which 36.7 million adults, 1.7 million children (< 15 years …
Immunodeficiency Virus (HIV), of which 36.7 million adults, 1.7 million children (< 15 years …
[HTML][HTML] HIV-1 selectively targets gut-homing CCR6+ CD4+ T cells via mTOR-dependent mechanisms
D Planas, Y Zhang, P Monteiro, JP Goulet, A Gosselin… - JCI insight, 2017 - ncbi.nlm.nih.gov
Gut-associated lymphoid tissues are enriched in CCR6+ Th17-polarized CD4+ T cells that
contribute to HIV-1 persistence during antiretroviral therapy (ART). This raises the need for …
contribute to HIV-1 persistence during antiretroviral therapy (ART). This raises the need for …
Dynamics and epigenetic signature of regulatory T-cells following antiretroviral therapy initiation in acute HIV infection
Background HIV infection promotes the expansion of immunosuppressive regulatory T-cells
(Tregs), contributing to immune dysfunction, tissue fibrosis and disease progression. Early …
(Tregs), contributing to immune dysfunction, tissue fibrosis and disease progression. Early …
The dynamics of γδ T cell responses in nonhuman primates during SARS-CoV-2 infection
AC Fears, EM Walker, N Chirichella… - Communications …, 2022 - nature.com
Although most SARS-CoV-2 infections are mild, some patients develop systemic
inflammation and progress to acute respiratory distress syndrome (ARDS). However, the …
inflammation and progress to acute respiratory distress syndrome (ARDS). However, the …
The role of glutathione in the management of cell-mediated immune responses in individuals with HIV
N Lin, T Erdos, C Louie, R Desai, N Lin… - International Journal of …, 2024 - mdpi.com
Human immunodeficiency virus (HIV) is a major cause of death worldwide. Without
appropriate antiretroviral therapy, the infection can develop into acquired immunodeficiency …
appropriate antiretroviral therapy, the infection can develop into acquired immunodeficiency …