Viral vector platforms within the gene therapy landscape

JT Bulcha, Y Wang, H Ma, PWL Tai… - Signal transduction and …, 2021 - nature.com
Throughout its 40-year history, the field of gene therapy has been marked by many
transitions. It has seen great strides in combating human disease, has given hope to patients …

Gene therapy leaves a vicious cycle

R Goswami, G Subramanian, L Silayeva… - Frontiers in …, 2019 - frontiersin.org
The human genetic code encrypted in thousands of genes holds the secret for synthesis of
proteins that drive all biological processes necessary for normal life and death. Though the …

Viral vector-based gene therapy

X Li, Y Le, Z Zhang, X Nian, B Liu, X Yang - International Journal of …, 2023 - mdpi.com
Gene therapy is a technique involving the modification of an individual's genes for treating a
particular disease. The key to effective gene therapy is an efficient carrier delivery system …

Adenoviral vector-based vaccine platform for COVID-19: Current status

VP Chavda, R Bezbaruah, D Valu, B Patel, A Kumar… - Vaccines, 2023 - mdpi.com
The coronavirus disease (COVID-19) breakout had an unimaginable worldwide effect in the
21st century, claiming millions of lives and putting a huge burden on the global economy …

[HTML][HTML] Viral and nonviral delivery systems for gene delivery

N Nayerossadat, T Maedeh, PA Ali - Advanced biomedical …, 2012 - journals.lww.com
Gene therapy is the process of introducing foreign genomic materials into host cells to elicit
a therapeutic benefit. Although initially the main focus of gene therapy was on special …

Viral vectors for gene therapy: translational and clinical outlook

MA Kotterman, TW Chalberg… - Annual review of …, 2015 - annualreviews.org
In a range of human trials, viral vectors have emerged as safe and effective delivery vehicles
for clinical gene therapy, particularly for monogenic recessive disorders, but there has also …

Viral vector systems for gene therapy: a comprehensive literature review of progress and biosafety challenges

S Ghosh, AM Brown, C Jenkins, K Campbell - Applied Biosafety, 2020 - liebertpub.com
Introduction: National Institutes of Health (NIH) defines gene therapy as an experimental
technique that uses genes to treat or prevent disease. Although gene therapy is a promising …

[HTML][HTML] MSC based gene delivery methods and strategies improve the therapeutic efficacy of neurological diseases

H Zhou, Y He, W Xiong, S Jing, X Duan, Z Huang… - Bioactive materials, 2023 - Elsevier
Mesenchymal stem cells (MSCs) are promising seed cells for neural regeneration therapy
owing to their plasticity and accessibility. They possess several inherent characteristics …

Gene therapies for cancer: strategies, challenges and successes

SK Das, ME Menezes, S Bhatia… - Journal of cellular …, 2015 - Wiley Online Library
Gene therapy, which involves replacement of a defective gene with a functional, healthy
copy of that gene, is a potentially beneficial cancer treatment approach particularly over …

Intervertebral disc degeneration—Current therapeutic options and challenges

A Samanta, T Lufkin, P Kraus - Frontiers in Public Health, 2023 - frontiersin.org
Degeneration of the intervertebral disc (IVD) is a normal part of aging. Due to the spine's
declining function and the development of pain, it may affect one's physical health, mental …