Clostridioides difficile is a Gram-positive anaerobe that can cause a spectrum of disorders
that range in severity from mild diarrhoea to fulminant colitis and/or death. The bacterium …

Clostridium difficile is a major cause of intestinal infection and diarrhoea in individuals
following antibiotic treatment. Recent studies have begun to elucidate the mechanisms that …

Clostridium difficile is a bacterial pathogen that is the leading cause of nosocomial antibiotic-
associated diarrhea and pseudomembranous colitis worldwide. The incidence, severity …

Clostridioides difficile is the most common cause of nosocomial antibiotic-associated
diarrhea, and is responsible for a spectrum of diseases characterized by high levels of …

Clostridium difficile is the cause of antibiotics-associated diarrhea and pseudomembranous
colitis. The pathogen produces three protein toxins: C. difficile toxins A (TcdA) and B (TcdB) …

Clostridium difficile infection (CDI) has significant clinical impact especially on the elderly
and/or immunocompromised patients. The pathogenicity of Clostridium difficile is mainly …

Large clostridial toxins (LCTs) are a family of bacterial exotoxins that infiltrate and destroy
target cells. Members of the LCT family include Clostridioides difficile toxins TcdA and TcdB …

The species composition of the human gut microbiota is related to overall health, and a
healthy gut microbiome is crucial in maintaining colonization resistance against pathogens …

Many bacterial pathogens produce protein toxins to outmanoeuvre the immune system of
the host. Some of these proteins target regulatory GTPases such as those belonging to the …

The worldwide emergence of epidemic strains of Clostridium difficile linked to increased
disease severity and mortality has resulted in greater research efforts toward determining …