Introduction: Mitochondria are cellular organelles that perform numerous bioenergetic,
biosynthetic, and regulatory functions and play a central role in iron metabolism …

Iron-sulfur (Fe-S) clusters are ubiquitous cofactors composed of iron and inorganic sulfur.
They are required for the function of proteins involved in a wide range of activities, including …

Abstract Iron–sulfur (Fe–S) clusters are ancient, ubiquitous cofactors composed of iron and
inorganic sulfur. The combination of the chemical reactivity of iron and sulfur, together with …

Fe-S cofactors are composed of iron and inorganic sulfur in various stoichiometries. A
complex assembly pathway conducts their initial synthesis and subsequent binding to …

Iron–sulfur (Fe/S) proteins are a class of ubiquitous components that assist in vital and
diverse biochemical tasks in virtually every living cell. These tasks include respiration, iron …

Iron sulfur (Fe-S) clusters, preassembled on the ISCU scaffold, are transferred to target
proteins or to intermediate scaffolds by a dedicated chaperone-cochaperone system …

The biogenesis of iron–sulfur (Fe–S) proteins in humans is a multistage process occurring in
different cellular compartments. The mitochondrial iron–sulfur cluster (ISC) assembly …

In recent years, iron sulfur (Fe–S) proteins have been identified as key players in
mammalian metabolism, ranging from long-known roles in the respiratory complexes and …

The major classes of molecular chaperones have highly variable sequences, sizes, and
shapes, yet they all bind to unfolded proteins, limit their aggregation, and assist in their …

Normal mode analysis (NMA) is a technique that can be used to describe the flexible states
accessible to a protein about an equilibrium position. These states have been shown …