[HTML][HTML] Advances in biomedical study of the myopia-related signaling pathways and mechanisms

J Yang, X Ouyang, H Fu, X Hou, Y Liu, Y Xie… - Biomedicine & …, 2022 - Elsevier
Myopia has become one of the most critical health problems in the world with the increasing
time spent indoors and increasing close work. Pathological myopia may have multiple …

The role of miR-29 family in TGF-β driven fibrosis in glaucomatous optic neuropathy

A Smyth, B Callaghan, CE Willoughby… - International Journal of …, 2022 - mdpi.com
Primary open angle glaucoma (POAG), a chronic optic neuropathy, remains the leading
cause of irreversible blindness worldwide. It is driven in part by the pro-fibrotic cytokine …

Exosomal miR-223 derived from natural killer cells inhibits hepatic stellate cell activation by suppressing autophagy

L Wang, Y Wang, J Quan - Molecular medicine, 2020 - Springer
Background Activation of hepatic stellate cells (HSCs) is a prominent driver of liver fibrosis.
We previously demonstrated that exosomes derived from natural killer (NK) cells (NK-Exo) …

Exosomes derived from natural killer cells inhibit hepatic stellate cell activation and liver fibrosis

L Wang, Y Wang, J Quan - Human cell, 2020 - Springer
Activation of hepatic stellate cells (HSCs) is a prominent driver of liver fibrosis. This study
was designed to investigate the effect of exosomes derived from natural killer (NK) cells on …

MicroRNA-29a inhibits collagen expression and induces apoptosis in human fetal scleral fibroblasts by targeting the Hsp47/Smad3 signaling pathway

X Tang, L Liu, S Liu, S Song, H Li - Experimental Eye Research, 2022 - Elsevier
Members of the microRNA-29 (miR-29) gene family have been implicated as suppressors of
collagen in several human diseases. The present study aimed to explore the function of miR …

Non‐coding RNAs and related molecules associated with form‐deprivation myopia in mice

S Liu, H Chen, W Ma, Y Zhong, Y Liang… - Journal of Cellular …, 2022 - Wiley Online Library
The role of miRNAs and its regulatory mechanism in myopia are indeterminate. Our study
aimed to investigate potential myopia‐associated non‐coding RNAs and related molecules …

MicroRNA-29a may influence myopia development by regulating collagen I

Y Zhu, Y Zhang, R Jiang, K Zhao, J Zhou - Current Eye Research, 2022 - Taylor & Francis
Purpose The aim of this study was to characterize the regulatory role of microRNA-29a (miR-
29a) in myopia, providing support for potential biomarkers and new therapeutic targets of …

[HTML][HTML] Exploration of the pathophysiology of high myopia via proteomic profiling of human corneal stromal lenticules

Y Yu, Z Zhang, F Xia, B Sun, S Liu, X Wang… - Experimental Eye …, 2024 - Elsevier
This study aimed to investigate the underlying pathophysiology of high myopia by analyzing
the proteome of human corneal stromal lenticule samples obtained through small incision …

[HTML][HTML] Effect of scleral crosslinking using multiple doses of genipin on experimental progressive myopia in tree shrews

M El Hamdaoui, AM Levy, M Gaonkar… - … Vision Science & …, 2021 - iovs.arvojournals.org
Purpose: To evaluate the effect of scleral crosslinking (SXL) on slowing experimental
progressive myopia in tree shrew eyes using sub-Tenon's injections of genipin (GEN) at …

[HTML][HTML] The potential of brimonidine for myopia treatment: targeting MMP-2 to regulate choroidal thickness and control eye growth

A Xiang, Z Peng, H He, X Meng, Y Luo, J Yang, F Zeng… - Heliyon, 2024 - cell.com
Drug treatment studies are a focal point for identifying novel approaches to reduce myopia
progression through basic science research. Here, we investigated the effects of various …