ZAP-70 in signaling, biology, and disease

BB Au-Yeung, NH Shah, L Shen… - Annual review of …, 2018 - annualreviews.org
T cells possess an array of functional capabilities important for host defense against
pathogens and tumors. T cell effector functions require the T cell antigen receptor (TCR) …

The CBM-opathies—a rapidly expanding spectrum of human inborn errors of immunity caused by mutations in the CARD11-BCL10-MALT1 complex

HY Lu, BM Bauman, S Arjunaraja, B Dorjbal… - Frontiers in …, 2018 - frontiersin.org
The caspase recruitment domain family member 11 (CARD11 or CARMA1)—B cell
CLL/lymphoma 10 (BCL10)—MALT1 paracaspase (MALT1)[CBM] signalosome complex …

Practice parameter for the diagnosis and management of primary immunodeficiency

FA Bonilla, DA Khan, ZK Ballas, J Chinen… - Journal of Allergy and …, 2015 - Elsevier
The American Academy of Allergy, Asthma & Immunology (AAAAI) and the American
College of Allergy, Asthma & Immunology (ACAAI) have jointly accepted responsibility for …

A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70

AY Chan, D Punwani, TA Kadlecek… - Journal of Experimental …, 2016 - rupress.org
A brother and sister developed a previously undescribed constellation of autoimmune
manifestations within their first year of life, with uncontrollable bullous pemphigoid, colitis …

Clinical, immunological, and genetic features in 49 patients with ZAP-70 deficiency: a systematic review

N Sharifinejad, M Jamee, M Zaki-Dizaji, B Lo… - Frontiers in …, 2020 - frontiersin.org
Background: Zeta-Chain Associated Protein Kinase 70 kDa (ZAP-70) deficiency is a rare
combined immunodeficiency (CID) caused by recessive homozygous/compound …

[HTML][HTML] Carbon ion (12C6+) irradiation induces the expression of Klrk1 in lung cancer and optimizes the tumor microenvironment based on the NKG2D/NKG2D-Ls …

J Wang, Z Dai, Y Miao, T Zhao, J Gan, C Zhao, J Ran… - Cancer Letters, 2021 - Elsevier
With the identification of “negative immune regulation” defects in the immune system and the
continuous improvement of immunotherapy, natural killer cells (NK) have received more …

Combined immunodeficiencies with nonfunctional T lymphocytes

LD Notarangelo - Advances in immunology, 2014 - Elsevier
Immunodeficiencies with nonfunctional T cells comprise a heterogeneous group of
conditions characterized by altered function of T lymphocytes in spite of largely preserved T …

Long-term outcomes of hematopoietic stem cell transplantation for ZAP70 deficiency

GDE Cuvelier, TS Rubin, DA Wall… - Journal of clinical …, 2016 - Springer
ZAP70 deficiency is a rare T+ B+ NK+ combined immunodeficiency with limited outcome
data to help guide decisions around hematopoietic stem cell transplant (HSCT). We sought …

Autoimmunity in primary T-cell immunodeficiencies

G Azizi, A Ghanavatinejad, H Abolhassani… - Expert review of …, 2016 - Taylor & Francis
Primary immunodeficiency diseases (PID) are a genetically heterogeneous group of more
than 270 disorders that affect distinct components of both humoral and cellular arms of the …

Novel mutation of ZAP-70-related combined immunodeficiency: first case from the National Iranian Registry and review of the literature

A Shirkani, M Shahrooei, G Azizi… - Immunological …, 2017 - Taylor & Francis
ABSTRACT ZAP-70 deficiency is a rare autosomal recessive form of combined
immunodeficiency (CID) characterized by selective absence of circulating CD8 T cells with …