Comorbidities are a hallmark of stroke that both increase the incidence of stroke and worsen
outcome. Hypertension is prevalent in the stroke population and the most important …

Insulin resistance often refers to a pathological condition in which cells fail to respond to the
normal actions of insulin. Increasing literature has noted a critical role of insulin resistance in …

The middle cerebral artery occlusion (MCAO) model in rats closely imitates ischemic stroke
and is widely used. Existing instrumental methods provide a certain level of MCAO …

Therapeutic induction of collateral flow as a means to salvage tissue and improve outcome
from acute ischemic stroke is a promising approach in the era in which endovascular …

The goal of reperfusion therapy for acute ischemic stroke (AIS) is to restore cerebral blood
flow through recanalization of the occluded vessel. Unfortunately, successful recanalization …

Background and Purpose—MAGL (monoacylglycerol lipase) is an enzyme that hydrolyzes
the endocannabinoid 2-arachidonoylglycerol and regulates the production of arachidonic …

Background Hypertension is an important risk factor for cerebrovascular disease, including
stroke and dementia. Both in humans and animal models of hypertension …

Arterial hypertension is not only the leading risk factor for stroke, but also attributes to
impaired recovery and poor outcome. The latter could be explained by hypertensive …

This study measured the relationship between pial collateral (leptomeningeal anastomoses,
LMA) flow, intraparenchymal cortical cerebral blood flow (cCBF) and brain tissue …

Ischemic stroke research has enabled significant advancements in diagnosis, treatment, and
management of this debilitating disease, yet challenges remain standing in the way of better …