G protein-coupled dopamine receptors (D1, D2, D3, D4, and D5) mediate all of the
physiological functions of the catecholaminergic neurotransmitter dopamine, ranging from …

Cannabis is the most commonly used illicit drug worldwide, with~ 5 million daily users
worldwide. Emerging evidence supports a number of associations between cannabis and …

Schizophrenia is a devastating illness that affects up to 1% of the population; it is
characterized by a combination of positive symptoms, negative symptoms, and cognitive …

Psychotropic drugs acting on monoamine neurotransmission are major pharmacological
treatments for neuropsychiatric conditions such as schizophrenia, depression, bipolar …

BACKGROUND: Cannabis use is associated with an increased risk of psychosis. One study
has suggested that genetic variation in the AKT1 gene might influence this effect …

Neurotransmitters and neuromodulators, such as dopamine, participate in a wide range of
behavioral and cognitive functions in the adult brain, including movement, cognition, and …

MicroRNAs (miRNAs) are a large family of small non-coding RNAs which negatively control
gene expression at both the mRNA and protein levels. The number of miRNAs identified is …

Schizophrenia is a prevalent complex trait disorder manifested by severe neurocognitive
dysfunctions and lifelong disability. During the past few years several studies have provided …

Schizophrenia is characterized by reduced hippocampal volume, decreased dendritic spine
density, altered neuroplasticity signaling pathways, and cognitive deficits associated with …

Dopamine D2 receptor antagonism is a unifying property of all antipsychotic drugs in clinical
use. Remarkably, the effector molecules through which these medications exert their actions …