The direct functionalization of C (sp3)–H bonds is one of the most synthetically powerful
research areas in current organic synthesis. Organocatalytic C (sp3)–H bond activation …

Described herein is a chiral magnesium bisphosphate-catalyzed asymmetric double C (sp3)–
H bond functionalization triggered by a sequential hydride shift/cyclization process. This …

Nontraditional Reactions of Azomethine Ylides: Decarboxylative Three-Component Couplings
of α-Amino Acids | Journal of the American Chemical Society ACS ACS Publications C&EN …

Aminobenzaldehydes react with indoles in an unprecedented cascade reaction. This acid-
catalyzed redox-neutral annulation proceeds via a condensation/1, 5-hydride shift/ring …

Cyclic secondary amines and 2-hydroxybenzaldehydes or related ketones react to furnish
benzo [e][1, 3] oxazine structures in generally good yields. This overall redox-neutral amine …

Described herein is the first example of an aliphatic, nonbenzylic hydride shift/cyclization
sequence that contains two types of novel sp3-C− H functionalization:(1) construction of a …

The borane-catalyzed synthesis of dihydroquinoline-4-ones is developed. The amino-
substituted chalcones undergo a 1, 7-hydride shift upon Lewis acid activation to form a …

p300/CREB binding protein associated factor (PCAF/KAT2B) and general control
nonderepressible 5 (GCN5/KAT2A) are multidomain proteins that have been implicated in …

The hydride transfer initiated cyclization (“HT-cyclization”) of aryl alkyl ethers, which leads to
direct coupling of sp3 C− H bonds and activated alkenes, is reported. Readily available …

Herein we report a diastereoselective synthesis of medium-sized carbocycle-fused
piperidines via [1, n (n= 6, 7)]-[1, 5]-sequential hydride shift triggered double C (sp3)–H bond …