Highlights•The GP63 metalloprotease selectively degrades molecules involved in
membrane trafficking and nuclear physiology.•Cleavage of VAMP8 and Syt XI disrupts cross …

It is important to realize that leishmaniasis guidelines cannot always account for individual
variation among patients. They are not intended to supplant physician judgment with respect …

Objectives Leishmaniasis is a neglected and widespread parasitic disease that can lead to
serious health problems. The current review study aimed to synthesize the relationship …

Cutaneous and mucosal leishmaniasis, caused in South America by Leishmania
braziliensis, is difficult to cure by chemotherapy (primarily pentavalent antimonials [SbV]) …

Tegumentary Leishmaniasis (TL) is endemic in Latin America, and Brazil contributes
approximately 20 thousand cases per year. The pathogenesis of TL, however, is still not fully …

The presence of the endogenous Leishmania RNA virus 1 (LRV1) replicating stably within
some parasite species has been associated with the development of more severe forms of …

Knowledge of viral diversity is expanding greatly, but many lineages remain underexplored.
We surveyed RNA viruses in 52 cultured monoxenous relatives of the human parasite …

Cutaneous leishmaniasis is a complex infection that is caused by different species of
Leishmania and affects more than 2 million people in 88 countries. Identifying the …

Cutaneous leishmaniasis has various outcomes, ranging from self-healing reddened
papules to extensive open ulcerations that metastasise to secondary sites and are often …

Kinetoplastid parasites of the Leishmania genus cause several forms of leishmaniasis.
Leishmania species pathogenic to human are separated into two subgenera, Leishmania …