Bionic ordered structured hydrogels: structure types, design strategies, optimization mechanism of mechanical properties and applications

Y Wang, X Jiang, X Li, K Ding, X Liu, B Huang… - Materials …, 2023 - pubs.rsc.org
Natural organisms, such as lobsters, lotus, and humans, exhibit exceptional mechanical
properties due to their ordered structures. However, traditional hydrogels have limitations in …

Trends in droplet microfluidics: From droplet generation to biomedical applications

Z Chen, S Kheiri, EWK Young, E Kumacheva - Langmuir, 2022 - ACS Publications
Over the past decade, droplet microfluidics has attracted growing interest in biology,
medicine, and engineering. In this feature article, we review the advances in droplet …

Microfluidic arrays of breast tumor spheroids for drug screening and personalized cancer therapies

E Prince, S Kheiri, Y Wang, F Xu… - Advanced …, 2022 - Wiley Online Library
One of the obstacles limiting progress in the development of effective cancer therapies is the
shortage of preclinical models that capture the dynamic nature of tumor microenvironments …

Generation and manipulation of hydrogel microcapsules by droplet-based microfluidics for mammalian cell culture

H Huang, Y Yu, Y Hu, X He, OB Usta, ML Yarmush - Lab on a Chip, 2017 - pubs.rsc.org
Hydrogel microcapsules provide miniaturized and biocompatible niches for three-
dimensional (3D) in vitro cell culture. They can be easily generated by droplet-based …

4D biofabrication: 3D cell patterning using shape‐changing films

V Stroganov, J Pant, G Stoychev… - Advanced functional …, 2018 - Wiley Online Library
A novel approach for fabrication of 3D cellular structures using new thermosensitive shape‐
changing polymer films with photolithographically patterned surface—4D biofabrication is …

Oscillatory multiphase flow strategy for chemistry and biology

M Abolhasani, KF Jensen - Lab on a Chip, 2016 - pubs.rsc.org
Continuous multiphase flow strategies are commonly employed for high-throughput
parameter screening of physical, chemical, and biological processes as well as continuous …

Microfluidic arrays of dermal spheroids: A screening platform for active ingredients of skincare products

Z Chen, S Kheiri, A Gevorkian, EWK Young, V Andre… - Lab on a Chip, 2021 - pubs.rsc.org
Organotypic micrometre-size 3D aggregates of skin cells (multicellular spheroids) have
emerged as a promising in vitro model that can be utilized as an alternative of animal …

Computational modelling and big data analysis of flow and drug transport in microfluidic systems: a spheroid-on-a-chip study

S Kheiri, E Kumacheva, EWK Young - Frontiers in Bioengineering …, 2021 - frontiersin.org
Microfluidic tumour spheroid-on-a-chip platforms enable control of spheroid size and their
microenvironment and offer the capability of high-throughput drug screening, but drug …

Thermoplastic microfluidic devices for targeted chemical and biological applications

D Voicu, G Lestari, Y Wang, M DeBono, M Seo, S Cho… - RSC …, 2017 - pubs.rsc.org
Combining photolithography and hot embossing offers the capability of cost-efficient and
high-fidelity fabrication of polymer microfluidic devices, however, poor chemical resistance …

Microfluidics-based single-cell research for intercellular interaction

L Pang, J Ding, XX Liu, Z Kou, L Guo, X Xu… - Frontiers in Cell and …, 2021 - frontiersin.org
Intercellular interaction between cell–cell and cell–ECM is critical to numerous biology and
medical studies, such as stem cell differentiation, immunotherapy and tissue engineering …