Curved membranes are key features of intracellular organelles, and their generation
involves dynamic protein complexes. Here we describe the fundamental mechanisms such …

Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) comprise a
category of versatile drug delivery systems that have been used in the biomedical field for> …

Membrane proteins play a most important part in metabolism, signaling, cell motility,
transport, development, and many other biochemical and biophysical processes which …

Human genetics has indicated a causal role for the protein α-synuclein in the pathogenesis
of familial Parkinson's disease (PD), and the aggregation of synuclein in essentially all …

Physiologically, α-synuclein chaperones soluble NSF attachment protein receptor (SNARE)
complex assembly and may also perform other functions; pathologically, in contrast, α …

It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

Abstract α-synuclein is a small protein abundantly expressed in the brain and mainly located
in synaptic terminals. The conversion of α-synuclein into oligomers and fibrils is the hallmark …

The normal functions and pathologic facets of the small presynaptic protein α-synuclein (α-
syn) are of exceptional interest. In previous studies, we found that α-syn attenuates synaptic …

Parkinson's disease (PD) is the second most progressive neurodegenerative disorder of the
aging population after Alzheimer's disease (AD). Defects in the lysosomal systems and …

Protein misfolding and aggregation are known to play a crucial role in a number of important
human diseases (Alzheimer's, Parkinson's, prion, diabetes, cataracts, etc.) as well as in a …