Biology and models of the blood–brain barrier

C Hajal, B Le Roi, RD Kamm… - Annual review of …, 2021 - annualreviews.org
The blood–brain barrier (BBB) is one of the most selective endothelial barriers. An
understanding of its cellular, morphological, and biological properties in health and disease …

Emerging application of nanorobotics and artificial intelligence to cross the BBB: advances in design, controlled maneuvering, and targeting of the barriers

AV Singh, V Chandrasekar… - ACS chemical …, 2021 - ACS Publications
The blood–brain barrier (BBB) is a prime focus for clinicians to maintain the homeostatic
function in health and deliver the theranostics in brain cancer and number of neurological …

The choroid plexus: a missing link in our understanding of brain development and function

NR Saunders, KM Dziegielewska… - Physiological …, 2023 - journals.physiology.org
Studies of the choroid plexus lag behind those of the more widely known blood-brain barrier,
despite a much longer history. This review has two overall aims. The first is to outline long …

In vitro blood brain barrier models: An overview

E Jagtiani, M Yeolekar, S Naik, V Patravale - Journal of Controlled Release, 2022 - Elsevier
Understanding the composition and function of the blood brain barrier (BBB) enables the
development of novel, innovative techniques for administering central nervous system …

Micropatterned neurovascular interface to mimic the blood–brain barrier's neurophysiology and micromechanical function: a BBB-on-CHIP model

AV Singh, V Chandrasekar, P Laux, A Luch, SP Dakua… - Cells, 2022 - mdpi.com
A hybrid blood–brain barrier (BBB)-on-chip cell culture device is proposed in this study by
integrating microcontact printing and perfusion co-culture to facilitate the study of BBB …

Induced pluripotent stem cell-based organ-on-a-chip as personalized drug screening tools: A focus on neurodegenerative disorders

F Fanizza, M Campanile, G Forloni… - Journal of Tissue …, 2022 - journals.sagepub.com
The Organ-on-a-Chip (OoC) technology shows great potential to revolutionize the drugs
development pipeline by mimicking the physiological environment and functions of human …

Evolving new-age strategies to transport therapeutics across the blood-brain-barrier

M Choudhari, S Hejmady, RN Saha, S Damle… - International Journal of …, 2021 - Elsevier
A basic understanding of the blood–brain barrier (BBB) is essential for the novel
advancements in targeting drugs specific to the brain. Neoplasm compromising the internal …

Blood-brain barrier models: Rationale for selection

AS Hanafy, D Dietrich, G Fricker… - Advanced Drug Delivery …, 2021 - Elsevier
Brain delivery is a broad research area, the outcomes of which are far hindered by the
limited permeability of the blood–brain barrier (BBB). Over the last century, research has …

Blood–Brain Barrier Breakdown in Neuroinflammation: Current In Vitro Models

S Brandl, M Reindl - International Journal of Molecular Sciences, 2023 - mdpi.com
The blood–brain barrier, which is formed by tightly interconnected microvascular endothelial
cells, separates the brain from the peripheral circulation. Together with other central nervous …

Continuous Monitoring Reveals Protective Effects of N‐Acetylcysteine Amide on an Isogenic Microphysiological Model of the Neurovascular Unit

I Matthiesen, D Voulgaris, P Nikolakopoulou… - Small, 2021 - Wiley Online Library
Microphysiological systems mimic the in vivo cellular ensemble and microenvironment with
the goal of providing more human‐like models for biopharmaceutical research. In this study …