(1) Background: Reactive oxygen species (ROS) play a crucial role in the preparation of the
normal wound healing response. Therefore, a correct balance between low or high levels of …

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by inappropriate
hyperglycemia due to lack of or resistance to insulin. Patients with DM are frequently afflicted …

Significance: Impaired wound healing is a major complication of diabetes, and can lead to
development of chronic foot ulcers in a significant number of patients. Despite the danger …

Impairment in diabetic wound healing constitutes an enormous biomedical burden. The
receptor for advanced glycation end-products (RAGE) expression in the diabetic cutaneous …

Although an abundant amount of research has been devoted to the study of angiogenesis,
its precise mechanisms are incompletely understood. Numerous clinical trials focused on …

Diabetic foot ulcers (DFUs) are significant complications of diabetes and an unmet medical
need. Matrix metalloproteinases (MMPs) play important roles in the pathology of wounds …

N‑acetylcysteine is a mucolytic drug which is commonly used as an antidote for
acetaminophen toxicity. It is a thiol compound, which acts as a donor of cysteine, leading to …

Chronic hyperglycemia impairs intracellular redox homeostasis and contributes to impaired
diabetic tissue regeneration. The Keap1/Nrf2 pathway is a critical regulator of the …

Vascular growth and remodeling responses entail several complex biochemical, molecular,
and cellular responses centered primarily on endothelial cell activation and function. Recent …

Lewisite is a highly toxic chemical warfare agent that leads to cutaneous and systemic
damage. N-acetylcysteine (NAC) and 4-phenylbutryic acid (4-PBA) are two novel antidotes …