The role of peptide hormones discovered in the 21st century in the regulation of adipose tissue functions

PA Kołodziejski, E Pruszyńska-Oszmałek… - Genes, 2021 - mdpi.com
Peptide hormones play a prominent role in controlling energy homeostasis and metabolism.
They have been implicated in controlling appetite, the function of the gastrointestinal and …

Orphan G protein coupled receptors in affective disorders

LR Watkins, C Orlandi - Genes, 2020 - mdpi.com
G protein coupled receptors (GPCRs) are the main mediators of signal transduction in the
central nervous system. Therefore, it is not surprising that many GPCRs have long been …

Effect of the neuropeptide phoenixin and its receptor GPR173 during folliculogenesis

XP Nguyen, T Nakamura, S Osuka, B Bayasula… - …, 2019 - rep.bioscientifica.com
Folliculogenesis is a complex process, defined by the growth and development of follicles
from the primordial population. Granulosa cells (GCs) play a vital role in every stage of …

[HTML][HTML] Neuroendocrinology of reproduction: Is gonadotropin-releasing hormone (GnRH) dispensable?

KE Whitlock, J Postlethwait, J Ewer - Frontiers in neuroendocrinology, 2019 - Elsevier
Gonadotropin releasing hormone (GnRH) is a highly conserved neuroendocrine
decapeptide that is essential for the onset of puberty and the maintenance of the …

Phoenixin-20 suppresses lipopolysaccharide-induced inflammation in dental pulp cells

G Sun, Q Ren, L Bai, L Zhang - Chemico-Biological Interactions, 2020 - Elsevier
Pulpal infection is one of the most common causes of dental emergency admission. Tooth
pain due to infection caused by gram-negative bacteria is the main manifestation of this sort …

The regulation of phoenixin: A fascinating multidimensional peptide

EK McIlwraith, N Zhang… - Journal of the Endocrine …, 2022 - academic.oup.com
The phoenixin (PNX) peptide is linked to the control of reproduction, food intake, stress, and
inflammation. However, little is known about what regulates its gene and protein expression …

Longitudinal study on novel neuropeptides phoenixin, spexin and kisspeptin in adolescent inpatients with anorexia nervosa–association with psychiatric symptoms

A Pałasz, M Tyszkiewicz-Nwafor… - Nutritional …, 2021 - Taylor & Francis
Objectives It is hypothesized that novel neuropeptides such as phoenixin (PNX), spexin
(SPX), and kisspeptin (KISS) are involved in the pathogenesis of eating disorders. The study …

Phoenixin 14 inhibits high-fat diet-induced non-alcoholic fatty liver disease in experimental mice

F Yang, P Huang, L Shi, F Liu, A Tang… - Drug Design …, 2020 - Taylor & Francis
Introduction Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic
liver diseases. The development of NAFLD is closely associated with hepatic lipotoxicity …

Phoenixin 14 inhibits ischemia/reperfusion-induced cytotoxicity in microglia

H Ma, D Su, Q Wang, Z Chong, Q Zhu, W He… - Archives of biochemistry …, 2020 - Elsevier
The process of ischemia/reperfusion (IR) in ischemic stroke often leads to significant cell
death and permanent neuronal damage. Safe and effective treatments are urgently needed …

The Gn RH analogues affect novel neuropeptide SMIM 20/phoenixin and GPR 173 receptor expressions in the female rat hypothalamic–pituitary–gonadal (HPG) axis

A Suszka‐Świtek, A Pałasz, Ł Filipczyk… - Clinical and …, 2019 - Wiley Online Library
The recently discovered peptide phoenixin (PNX) and its receptor GPR 173 are novel factors
that exhibit a large spectrum of regulatory activity, especially when considered as a central …