Alzheimer's disease as type 3 diabetes: common pathophysiological mechanisms between Alzheimer's disease and type 2 diabetes

M Michailidis, D Moraitou, DA Tata, K Kalinderi… - International journal of …, 2022 - mdpi.com
Globally, the incidence of type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD)
epidemics is increasing rapidly and has huge financial and emotional costs. The purpose of …

[HTML][HTML] Is Alzheimer's disease a type 3 diabetes? A critical appraisal

R Kandimalla, V Thirumala, PH Reddy - Biochimica et Biophysica Acta …, 2017 - Elsevier
Recently researchers proposed the term 'Type-3-Diabetes' for Alzheimer's disease (ad)
because of the shared molecular and cellular features among Type-1-Diabetes, Type-2 …

Adaptive immune cells shape obesity-associated type 2 diabetes mellitus and less prominent comorbidities

S SantaCruz-Calvo, L Bharath, G Pugh… - Nature Reviews …, 2022 - nature.com
Obesity and type 2 diabetes mellitus (T2DM) are increasing in prevalence owing to
decreases in physical activity levels and a shift to diets that include addictive and/or high …

Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers

C Reitz, R Mayeux - Biochemical pharmacology, 2014 - Elsevier
The global prevalence of dementia is as high as 24 million, and has been predicted to
quadruple by the year 2050. In the US alone, Alzheimer disease (AD)–the most frequent …

Exercise programs for people with dementia

D Forbes, SC Forbes, CM Blake… - Cochrane database …, 2015 - cochranelibrary.com
Background This is an update of our previous 2013 review. Several recent trials and
systematic reviews of the impact of exercise on people with dementia are reporting …

Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial

S Craft, LD Baker, TJ Montine, S Minoshima… - Archives of …, 2012 - jamanetwork.com
Objective To examine the effects of intranasal insulin administration on cognition, function,
cerebral glucose metabolism, and cerebrospinal fluid biomarkers in adults with amnestic …

Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the …

P Lewczuk, P Riederer, SE O'bryant… - The world journal of …, 2018 - Taylor & Francis
In the 12 years since the publication of the first Consensus Paper of the WFSBP on
biomarkers of neurodegenerative dementias, enormous advancement has taken place in …

Insulin in the brain: there and back again

WA Banks, JB Owen, MA Erickson - Pharmacology & therapeutics, 2012 - Elsevier
Insulin performs unique functions within the CNS. Produced nearly exclusively by the
pancreas, insulin crosses the blood–brain barrier (BBB) using a saturable transporter …

Effects of aerobic exercise on mild cognitive impairment: a controlled trial

LD Baker, LL Frank, K Foster-Schubert… - Archives of …, 2010 - jamanetwork.com
Objectives To examine the effects of aerobic exercise on cognition and other biomarkers
associated with Alzheimer disease pathology for older adults with mild cognitive impairment …

Type 3 diabetes is sporadic Alzheimer׳ s disease: mini-review

SM de la Monte - European neuropsychopharmacology, 2014 - Elsevier
Alzheimer׳ s disease (AD) is the most common cause of dementia in North America.
Growing evidence supports the concept that AD is a metabolic disease mediated by …