Genomic analyses estimated that the proportion of the genome encoding proteins
corresponds to approximately 1.5%, while at least 66% are transcribed, suggesting that …

A fundamental goal in biology is to understand how distinct cell types containing the same
genetic information arise from a single stem cell throughout development. Sex determination …

The roles of EZH2 in various subsets of CD4+ T cells are controversial and its mechanisms
of action are incompletely understood. FOXP3-positive Treg cells are a critical helper T cell …

TRPM7 is a ubiquitous ion channel and kinase, a unique" chanzyme," required for proper
early embryonic development. It conducts Zn 2+, Mg 2+, and Ca 2+ as well as monovalent …

During the chronic stage of Schistosoma infection, the female lays fertile eggs, triggering a
strong anti‐parasitic type 2 helper T‐cell (Th2) immune response. It is unclear how this Th2 …

Cohesin is crucial for proper chromosome segregation but also regulates gene transcription
and organism development by poorly understood mechanisms. Using genome-wide assays …

XX and XY fetal gonads are initially bipotential, poised between the ovary and testis fate.
Multiple lines of evidence suggest that commitment to testis fate requires the repression of …

The HIV Nef protein recruits the polycomb protein Eed and mimics an integrin receptor
signal for reasons that are not entirely clear. Here we demonstrate that Nef and Eed complex …

Polycomb group (PcG) proteins are known to repress developmental genes during
embryonic development and tissue homeostasis. Here, we report that PCGF6 controls …

Objective EZH2 is an epigenetic regulator that mediates H3K27 trimethylation (H3K27me3)
and modulates DNA methylation. The aim of this study was to characterize the role of EZH2 …