The human virome: assembly, composition and host interactions

G Liang, FD Bushman - Nature Reviews Microbiology, 2021 - nature.com
The human body hosts vast microbial communities, termed the microbiome. Less well
known is the fact that the human body also hosts vast numbers of different viruses …

[HTML][HTML] Strategies to overcome the main challenges of the use of CRISPR/Cas9 as a replacement for cancer therapy

MF Rasul, BM Hussen, A Salihi, BS Ismael, PJ Jalal… - Molecular Cancer, 2022 - Springer
CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats-associated protein
9) shows the opportunity to treat a diverse array of untreated various genetic and …

The resistance mechanisms of bacteria against ciprofloxacin and new approaches for enhancing the efficacy of this antibiotic

A Shariati, M Arshadi, MA Khosrojerdi… - Frontiers in public …, 2022 - frontiersin.org
For around three decades, the fluoroquinolone (FQ) antibiotic ciprofloxacin has been used
to treat a range of diseases, including chronic otorrhea, endocarditis, lower respiratory tract …

[HTML][HTML] The resurgence of phage-based therapy in the era of increasing antibiotic resistance: from research progress to challenges and prospects

NJ Anyaegbunam, CC Anekpo… - Microbiological …, 2022 - Elsevier
Phage therapy was implemented almost a century ago but was subsequently abandoned
when antibiotics emerged. However, the rapid emergence of drug-resistant, which has …

Klebsiella pneumonia and Its Antibiotic Resistance: A Bibliometric Analysis

Y Li, S Kumar, L Zhang, H Wu - BioMed research international, 2022 - Wiley Online Library
The rapid development of antibiotic resistance in K. pneumonia has led to a major concern.
In order to analyze the hotspots and develop trends in this field through visual the analysis …

Bacteriophages, a new therapeutic solution for inhibiting multidrug-resistant bacteria causing wound infection: lesson from animal models and clinical trials

M Taati Moghadam, A Khoshbayan… - Drug design …, 2020 - Taylor & Francis
Wound infection kills a large number of patients worldwide each year. Staphylococcus
aureus, Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa …

Bacteriophage as a novel therapeutic weapon for killing colistin-resistant multi-drug-resistant and extensively drug-resistant gram-negative bacteria

SM Mousavi, S Babakhani, L Moradi, S Karami… - Current …, 2021 - Springer
Colistin-resistant multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-
resistant (PDR) bacteria are highly lethal and many researchers have tried hard to combat …

Phage therapy for pulmonary infections: lessons from clinical experiences and key considerations

G Mitropoulou, A Koutsokera, C Csajka… - European …, 2022 - Eur Respiratory Soc
Lower respiratory tract infections lead to significant morbidity and mortality. They are
increasingly caused by multidrug-resistant pathogens, notably in individuals with cystic …

The age of phage: friend or foe in the new dawn of therapeutic and biocontrol applications?

AY Hassan, JT Lin, N Ricker, H Anany - Pharmaceuticals, 2021 - mdpi.com
Extended overuse and misuse of antibiotics and other antibacterial agents has resulted in
an antimicrobial resistance crisis. Bacteriophages, viruses that infect bacteria, have …

[HTML][HTML] Design of Phage-Cocktail–Containing Hydrogel for the Treatment of Pseudomonas aeruginosa–Infected Wounds

F Shafigh Kheljan, F Sheikhzadeh Hesari… - Viruses, 2023 - mdpi.com
Recently, the treatment of infected wounds has become a global problem due to increased
antibiotic resistance in bacteria. The Gram-negative opportunistic pathogen Pseudomonas …