One of the major challenges of bottom-up synthetic biology is rebuilding a minimal cell
division machinery. From a reconstitution perspective, the animal cell division apparatus is …

When stretched, cells cultured on 2D substrates share a universal softening and fluidization
response that arises from poorly understood remodeling of well-conserved cytoskeletal …

Phagocytosis of invading pathogens or cellular debris requires a dramatic change in cell
shape driven by actin polymerization. For antibody-covered targets, phagocytosis is thought …

Myosin IC, a single-headed member of the myosin I family, specifically interacts with anionic
phosphatidylinositol 4, 5-bisphosphate (PI [4, 5] P2) in the cell membrane via the pleckstrin …

Simple Summary Here, we review the known characteristics and functions of proteins called
myosin-I. These mechanoenzymes belong to an ancient family of actin-dependent motors …

Rationale: Patients with chronic kidney disease (CKD) have an exceedingly high
cardiovascular risk; which further increases in patients on peritoneal dialysis (PD). The …

Background Colorectal cancer (CRC) has a high worldwide incidence and mortality. Tumor
metastasis is one of the primary reasons for the poor prognosis of CRC patients. However …

MYCN amplification (MNA) is a defining feature of high-risk neuroblastoma (NB) and
predicts poor prognosis. However, whether genes within or in close proximity to the MYCN …

Vesicle trafficking and the establishment of apicobasal polarity are essential processes in
epithelial morphogenesis. UNC45A deficiency has been reported in a multi-organ syndrome …

The precise assembly and disassembly of actin filaments is required for several cellular
processes, and their regulation has been scrutinized for decades. Twenty years ago, a …