Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, also referred to
as drug-induced hypersensitivity syndrome, is a distinct, potentially life-threatening adverse …

Drug hypersensitivity reactions (DHR) are based on distinct mechanisms and are clinically
heterogeneous. Taking into account that also off‐target activities of drugs may lead to …

Because of a preconceived notion that eliminating reactive metabolite (RM) formation with
new drug candidates could mitigate the risk of idiosyncratic drug toxicity, the potential for RM …

Drug-induced hypersensitivity syndrome (DiHS), also known as drug reaction with
eosinophilia and systemic symptoms (DRESS), is a severe cutaneous adverse reaction …

Abstract An anticonvulsant, carbamazepine (CBZ), is known to show incidences of
cutaneous adverse drug reactions (cADRs) including Stevens–Johnson syndrome (SJS) …

Immune reactions to small molecular compounds, such as drugs, can cause a variety of
diseases involving the skin, liver, kidney, and lungs. In many drug hypersensitivity reactions …

Idiosyncratic drug reactions are a significant cause of morbidity and mortality for patients;
they also markedly increase the uncertainty of drug development. The major targets are skin …

Drug rash with eosinophilia and systemic symptoms syndrome is a severe idiosyncratic drug
reaction with a long latency period. It has been described using many terms; however, drug …

Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic
symptoms (DIHS/DRESS) is a severe type of adverse drug eruption associated with …

BACKGROUND: Increasing studies have revealed that HLA alleles are the major genetic
determinants of drug hypersensitivity; however, the underlying molecular mechanism …