Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

Different calcium signals in the endothelium and smooth muscle target different types of
Ca2+-sensitive K+ channels to modulate vascular function. These differential calcium …

Carbon monoxide (CO) is an endogenous paracrine and autocrine gaseous messenger that
regulates physiological functions in a wide variety of tissues. CO induces vasodilation by …

Ethanol exerts its biological actions through multiple receptors, including ion channels. Ion
channels that are sensitive to pharmacologically relevant ethanol concentrations constitute a …

Although it is now more than two decades since it was first reported that the
imidazobenzodiazepine Ro15-4513 reverses behavioral alcohol effects, the molecular …

Progesterone (≥ 1 µM) is used in recovery of cerebral ischemia, an effect likely contributed
to by cerebrovascular dilation. The targets of this progesterone action are unknown. We …

Alcohol misuse has deleterious effects on personal health, family, societal units, and global
economies. Moreover, alcohol misuse usually leads to several diseases and conditions …

Enhanced acute tolerance predicts alcohol abuse. We describe work on the role of the
calcium-and voltage-gated BK channel in alcohol tolerance, highlighting the lipid …

Ethanol alters BK (slo1) channel function leading to perturbation of physiology and behavior.
Site (s) and mechanism (s) of ethanol–BK channel interaction are unknown. We …

Large conductance, calcium-and voltage-gated potassium (BK) channels are ubiquitous and
critical for neuronal function, immunity, and smooth muscle contractility. BK channels are …