The DNA topoisomerase enzymes are essential to cell function and are found ubiquitously
in all domains of life. The various topoisomerase enzymes perform a wide range of functions …

The topoisomerase enzymes play an important role in DNA metabolism, and searching for
enzyme inhibitors is an important target in the search for new anticancer drugs. Discovery of …

DNA topoisomerase II (topo II) is an important enzyme involved in DNA replication,
recombination, and repair. Despite the popular applications of topo II inhibitors in cancer …

Inducing necroptosis in cancer cells is an effective approach to circumvent drug‐resistance.
Metal‐based triggers have, however, rarely been reported. Ruthenium (II) complexes …

A TfOH-promoted synthesis of fluorinated polyfused heterocycles via the cascade cyclization
of azadienes and difluoroenoxysilanes has been developed, leading to the facile …

DNA Topoisomerases (Topos) are ubiquitous nuclear enzymes involved in regulating the
topological state of DNA and, in eukaryotic organisms, Topos can be classified into two …

Transition metal-catalyzed skeletal rearrangement reactions have rapid advances in organic
community. Their development benefits synthetic methodologies by providing versatile and …

A series of new podophyllotoxin linked β-carboline congeners have been synthesized by
coupling various substituted β-carboline acids with 4β-aminopodophyllotoxin. Evaluation of …

Structural derivatization of natural products has been a continuing and irreplaceable source
of novel drug leads. Natural phenols are a broad category of natural products with wide …

Introduction The fused aromatic system of terpyridines makes them good, innocent ligands
for various metals. The resulting complexes have been extensively studied for both their …