Background Perioperative blood loss is a major concern in spinal fusion surgery and often
requires blood transfusion. A large amount of perioperative blood loss might increase the …

Objectives To examine the pharmacokinetics (PK) and pharmacodynamics of a tranexamic
(TXA) regimen designed for cardiac surgery with cardiopulmonary bypass (CPB). Design A …

Background Heparin management in hemophilia A (HA) patients with a factor VIII (FVIII)
inhibitor can be challenging due to severe activated clotting time (ACT) prolongations. It is …

Antifibrinolytic therapy is a pharmacologic cornerstone of a multimodal blood conservation
program in cardiac surgery with or without cardiopulmonary bypass (CPB). 1 The …

The antifibrinolytic agent aminocaproic acid (ACA) is occasionally used prior to episodes of
intense training in racehorses suffering from exercise‐induced pulmonary hemorrhage …

Abstract Purpose of Review This review describes the latest information related to the
administration of lysine analogues during cardiac surgery. An awareness of appropriate …

Hemophilia A and B are X-linked, recessive bleeding disorders without racial, ethnic, or
geographic limitations. 1 Although commonly inherited, spontaneous genetic mutations can …

Die Gabe von Lysinanaloga ist mit dem Auftreten von Krampfanfällen assoziiert. In dieser
Arbeit wurde die Wirkung von ε-Aminocapronsäure auf die synaptische Übertragung und …

Background: Bleeding after cardiac surgery is a well-known serious complication. Cardiac
surgical patients are particularly susceptible to postoperative mediastinal bleeding …

En las últimas décadas, con el incremento de los procedimientos médicos mayores como
cirugías cardíacas, trasplantes de órgano sólido, y de los accidentes en carretera, la …