Triplet therapy, transplantation, and maintenance until progression in myeloma

PG Richardson, SJ Jacobus, EA Weller… - … England Journal of …, 2022 - Mass Medical Soc
Background In patients with newly diagnosed multiple myeloma, the effect of adding
autologous stem-cell transplantation (ASCT) to triplet therapy (lenalidomide, bortezomib …

Role of minimal residual disease assessment in multiple myeloma

RE Szalat, KC Anderson, NC Munshi - Haematologica, 2024 - pmc.ncbi.nlm.nih.gov
Multiple myeloma (MM) is a hematologic malignancy characterized by clonal proliferation of
plasma cells. MM is a heterogeneous disease, featured by various molecular subtypes with …

Minimal residual disease in multiple myeloma: past, present, and future

A Medina-Herrera, ME Sarasquete, C Jiménez, N Puig… - Cancers, 2023 - mdpi.com
Simple Summary The assessment of responses is critical in patients diagnosed with multiple
myeloma. Nowadays, one of the most informative parameters to discriminate responses to …

MRD dynamics during maintenance for improved prognostication of 1280 patients with myeloma in the TOURMALINE-MM3 and-MM4 trials

B Paiva, I Manrique, MA Dimopoulos, F Gay, CK Min… - Blood, 2023 - ashpublications.org
Measurable residual disease (MRD) evaluation may help to guide treatment duration in
multiple myeloma (MM). Paradoxically, limited longitudinal data exist on MRD during …

[HTML][HTML] Clonal hematopoiesis with DNMT3A and PPM1D mutations impairs regeneration in autologous stem cell transplant recipients

P Stelmach, S Richter, S Sauer, MA Fabre, M Gu… - …, 2023 - ncbi.nlm.nih.gov
Clonal hematopoiesis (CH) is an age-related condition driven by stem and progenitor cells
harboring recurrent mutations linked to myeloid neoplasms. Currently, potential effects on …

Measurable residual disease and decision-making in multiple myeloma

BA Derman, R Fonseca - Hematology/Oncology Clinics, 2024 - hemonc.theclinics.com
Measurable (or minimal) residual disease (MRD) in multiple myeloma (MM) refers to low
levels of myeloma cells detectable using advanced diagnostics. MRD testing is evolving …

Targeted Delivery of c (RGDfk)‐Modified Liposomes to Bone Marrow Through In Vivo Hitchhiking Neutrophils for Multiple Myeloma Therapy

H Liu, B Zhang, H Chen, H Wang, X Qin… - Advanced …, 2024 - Wiley Online Library
Multiple myeloma (MM) is a prevalent bone marrow disorder. The challenges in managing
MM include selecting chemotherapy regimens that effectively modulate the myeloma …

[HTML][HTML] МНОЖЕСТВЕННОЙ МИЕЛОМЫ: ДИАГНОСТИКА И ТЕРАПИЯ (ЧАСТЬ 2)

СС Бессмельцев - Вестник гематологии, 2022 - cyberleninka.ru
Использование новых подходов в лечении рецидивов и рефрактерных форм
множественной миеломы (ММ) привело к существенному улучшению общей …

Clinical significance of complete remission and measurable residual disease in relapsed/refractory multiple myeloma patients treated with T‐cell redirecting …

A Zabaleta, N Puig, MT Cedena… - American Journal of …, 2025 - Wiley Online Library
The impact of measurable residual disease (MRD) in relapse/refractory multiple myeloma
(RRMM) patients treated with T‐cell redirecting immunotherapy is uncertain. We analyzed …

Impact of pretransplant minimal residual disease in patients with multiple myeloma and a very good partial response or better receiving autologous hematopoietic …

O Pasvolsky, S Pasyar, RL Bassett, HN Khan… - Cancer, 2024 - Wiley Online Library
Background The prognostic significance of minimal residual disease (MRD) status before
autologous hematopoietic stem cell transplantation (autoHCT) in patients with multiple …