How does the immune system enter the brain?

JA Mapunda, H Tibar, W Regragui… - Frontiers in …, 2022 - frontiersin.org
Multiple Sclerosis (MS) is considered the most frequent inflammatory demyelinating disease
of the central nervous system (CNS). It occurs with a variable prevalence across the world. A …

Meningeal immunity and its function in maintenance of the central nervous system in health and disease

K Alves de Lima, J Rustenhoven… - Annual review of …, 2020 - annualreviews.org
Neuroimmunology, albeit a relatively established discipline, has recently sparked numerous
exciting findings on microglia, the resident macrophages of the central nervous system …

Revisiting the mechanisms of CNS immune privilege

A Louveau, TH Harris, J Kipnis - Trends in immunology, 2015 - cell.com
Whereas the study of the interactions between the immune system and the central nervous
system (CNS) has often focused on pathological conditions, the importance of neuroimmune …

VE-cadherin in arachnoid and pia mater cells serves as a suitable landmark for in vivo imaging of CNS immune surveillance and inflammation

JA Mapunda, J Pareja, M Vladymyrov, E Bouillet… - Nature …, 2023 - nature.com
Meninges cover the surface of the brain and spinal cord and contribute to protection and
immune surveillance of the central nervous system (CNS). How the meningeal layers …

Structure and junctional complexes of endothelial, epithelial and glial brain barriers

M Castro Dias, JA Mapunda, M Vladymyrov… - International journal of …, 2019 - mdpi.com
The homeostasis of the central nervous system (CNS) is ensured by the endothelial,
epithelial, mesothelial and glial brain barriers, which strictly control the passage of …

The meninges as barriers and facilitators for the movement of fluid, cells and pathogens related to the rodent and human CNS

RO Weller, MM Sharp, M Christodoulides… - Acta …, 2018 - Springer
Meninges that surround the CNS consist of an outer fibrous sheet of dura mater
(pachymeninx) that is also the inner periosteum of the skull. Underlying the dura are the …

Tmem119-EGFP and Tmem119-CreERT2 transgenic mice for labeling and manipulating microglia

T Kaiser, G Feng - eneuro, 2019 - eneuro.org
Microglia are specialized brain-resident macrophages with important functions in health and
disease. To improve our understanding of these cells, the research community needs …

[HTML][HTML] Neurocristopathies: New insights 150 years after the neural crest discovery

GA Vega-Lopez, S Cerrizuela, C Tribulo… - Developmental biology, 2018 - Elsevier
The neural crest (NC) is a transient, multipotent and migratory cell population that generates
an astonishingly diverse array of cell types during vertebrate development. These cells …

The medium of haptic perception: a tensegrity hypothesis

MT Turvey, ST Fonseca - Journal of motor behavior, 2014 - Taylor & Francis
For any given animal, the sources of mechanical disturbances inducing tissue deformation
define environment from the perspective of the animal's haptic perceptual system. The …

It takes a village: constructing the neurogenic niche

CS Bjornsson, M Apostolopoulou, Y Tian, S Temple - Developmental cell, 2015 - cell.com
Although many features of neurogenesis during development and in the adult are intrinsic to
the neurogenic cells themselves, the role of the microenvironment is irrefutable. The …