Throughout life, T cells coordinate multiple aspects of adaptive immunity, including
responses to pathogens, allergens, and tumors. In mouse models, the role of T cells is …

Molecular, cellular, and clinical studies of human inborn errors of immunity have
revolutionized our understanding of their pathogenesis, considerably broadened their …

Background The function of the thymus in human adults is unclear, and routine removal of
the thymus is performed in a variety of surgical procedures. We hypothesized that the adult …

The extension of life span driven by 40% caloric restriction (CR) in rodents causes trade-offs
in growth, reproduction, and immune defense that make it difficult to identify therapeutically …

Following periods of haematopoietic cell stress, such as after chemotherapy, radiotherapy,
infection and transplantation, patient outcomes are linked to the degree of immune …

For many cancer types, incidence rises rapidly with age as an apparent power law,
supporting the idea that cancer is caused by a gradual accumulation of genetic mutations …

Importance Newborn screening for severe combined immunodeficiency (SCID) using
assays to detect T-cell receptor excision circles (TRECs) began in Wisconsin in 2008, and …

Naive T cells have long been regarded as a developmentally synchronized and fairly
homogeneous and quiescent cell population, the size of which depends on age, thymic …

Immunological memory is thought to depend on a stem cell–like, self-renewing population of
lymphocytes capable of differentiating into effector cells in response to antigen re-exposure …

There is an urgent need to understand the nature of immune responses against SARS-CoV-
2, to inform risk-mitigation strategies for people living with HIV (PLWH). Here we show that …