Molecular, cellular, and clinical studies of human inborn errors of immunity have revolutionized our understanding of their pathogenesis, considerably broadened their …
Background The function of the thymus in human adults is unclear, and routine removal of the thymus is performed in a variety of surgical procedures. We hypothesized that the adult …
The extension of life span driven by 40% caloric restriction (CR) in rodents causes trade-offs in growth, reproduction, and immune defense that make it difficult to identify therapeutically …
E Velardi, JJ Tsai, MRM van den Brink - Nature Reviews Immunology, 2021 - nature.com
Following periods of haematopoietic cell stress, such as after chemotherapy, radiotherapy, infection and transplantation, patient outcomes are linked to the degree of immune …
For many cancer types, incidence rises rapidly with age as an apparent power law, supporting the idea that cancer is caused by a gradual accumulation of genetic mutations …
A Kwan, RS Abraham, R Currier, A Brower… - Jama, 2014 - jamanetwork.com
Importance Newborn screening for severe combined immunodeficiency (SCID) using assays to detect T-cell receptor excision circles (TRECs) began in Wisconsin in 2008, and …
T van den Broek, JAM Borghans… - Nature Reviews …, 2018 - nature.com
Naive T cells have long been regarded as a developmentally synchronized and fairly homogeneous and quiescent cell population, the size of which depends on age, thymic …
Immunological memory is thought to depend on a stem cell–like, self-renewing population of lymphocytes capable of differentiating into effector cells in response to antigen re-exposure …
There is an urgent need to understand the nature of immune responses against SARS-CoV- 2, to inform risk-mitigation strategies for people living with HIV (PLWH). Here we show that …