Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) are the most abundant
phospholipids in all mammalian cell membranes. In the 1950s, Eugene Kennedy and co …

Understanding the function of genes mutated in hereditary forms of Parkinson's disease
yields insight into disease etiology and reveals new pathways in cell biology. Although …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Owing to the dominant functions of mitochondria in multiple cellular metabolisms and distinct
types of regulated cell death, maintaining a functional mitochondrial network is fundamental …

The interplay between mitochondrial energetics, lipid balance, and muscle insulin sensitivity
has remained a topic of intense interest and debate for decades. One popular view suggests …

Autophagy classically functions as a physiological process to degrade cytoplasmic
components, protein aggregates, and/or organelles, as a mechanism for nutrient …

The lipids that make up biological membranes tend to be the forgotten molecules of cell
biology. The paucity of data on these important entities likely reflects the difficulties of …

Aging is characterized by progressive decline in muscle mass, strength, and quality all of
which contribute to functional impairment, falls, mobility disability, and frailty. Circulating …

We investigated the link between enhancement of SI (by hyperinsulinemic–euglycemic
clamp) and muscle metabolites after 12 weeks of aerobic (high-intensity interval training …

Mitochondrial complex III (CIII) deficiency is a relatively rare disease with high clinical and
genetic heterogeneity. CIII comprises 11 subunits encoded by one mitochondrial and 10 …